Please use this identifier to cite or link to this item: http://hdl.handle.net/10201/73941

Title: Paneth cells are also target of the ribotoxic lectin nigrin b
Issue Date: 2014
Citation: Histology and Histopathology, vol. 29, nº 8, (2014)
ISSN: 1699-5848
0213-3911
Related subjects: CDU::5 - Ciencias puras y naturales::57 - Biología::576 - Biología celular y subcelular. Citología
Keywords: Paneth cells
Nigrin b
Lectin
RIP
Abstract: Ribosome-inactivating lectins (RILs) are AB type toxins like ricin whose molecular target is the large rRNA of eukaryotic ribosome. Administration of lethal doses of the RIL nigrin b isolated from elderberry (Sambucus nigra L.) bark triggers specific intestinal derangement. The aim of the present research was to explore the early effects of a lethal dose of nigrin b (16 mg/kg body weight) on the small intestine using light and electron microscopy to ascertain intestinal epithelium changes. 6 h after nigrin administration, the small intestine crypts began to show signs of damage with cells appearing at different stages of apoptosis. 16 h after injection crypts appeared more impaired, including the derangement of Paneth cells. The novelty of our results is that the Paneth cells in the small intestine in addition to stem cells are the early cellular targets for nigrin b.
Primary author: Jiménez, Pilar
Gayoso, Manuel José
Garrosa, Manuel
Córdoba-Díaz, Damián
Cabrero, Patricia
Tejero, Jesús
Aracil, Mónica
Girbés, Tomás
URI: http://hdl.handle.net/10201/73941
Document type: info:eu-repo/semantics/article
Number of pages / Extensions: 7
Rights: info:eu-repo/semantics/openAccess
Attribution-NonCommercial-NoDerivatives 4.0 International
Appears in Collections:Vol.29, nº 8 (2014)

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