Por favor, use este identificador para citar o enlazar este ítem: http://hdl.handle.net/10201/73487

Registro completo de metadatos
Campo DCValorLengua/Idioma
dc.contributor.authorSimonetti, S.-
dc.contributor.authorSerrano, C.-
dc.contributor.authorHernández-Losa, J.-
dc.contributor.authorBagué, S.-
dc.contributor.authorOrellana, R.-
dc.contributor.authorValverde, C.-
dc.contributor.authorLleonart, M. E.-
dc.contributor.authorAizpurua, M.-
dc.contributor.authorCarles, J.-
dc.contributor.authorRamón y Cajal, S.-
dc.contributor.authorRomagosa, C.-
dc.date.accessioned2019-07-09T14:17:36Z-
dc.date.available2019-07-09T14:17:36Z-
dc.date.issued2014-
dc.identifier.citationHistology and Histopathology, vol. 29, nº 6, (2014)es_ES
dc.identifier.issn1699-5848-
dc.identifier.issn0213-3911-
dc.identifier.urihttp://hdl.handle.net/10201/73487-
dc.description.abstractBackground: Schwannomas are benign nerve sheath tumors that only very rarely undergo malignant changes. Oncogenic-induced senescence is a defense mechanism against such malignant transformation. Different molecular pathways are involved in this process, such as RAS-RAF-MAPK. Based on the fact that the RAS-RAF-MAPK pathway is known to be activated in peripheral nerve sheath tumors, this study analyzes senescence markers in Schwannomas to demonstrate the possible role of senescence in their genesis. Methods: A retrospective immunohistochemical study was done in 39 schwannoma and 18 malignant peripheral nerve sheath tumors (MPNST). Staining for p16INK4a, Ki67, p53 and CyclinD1 was performed in all the cases. Additionally, ß-galactosidase staining was done in those cases in which frozen tissue was available (n=8). Results: Higher levels of p16INK4a (p=0.0001) and lower levels of Ki67 (p=0.0001) were found in Schwannomas. Beta-galactosidase activity was positive in 5/5 Schwannomas and negative in 3/3 MPNST. Conclusions: Our results support the senescence nature of Schwannomas and the absence of a senescence phenotype in MPNST.es_ES
dc.formatapplication/pdfes_ES
dc.format.extent10es_ES
dc.languageenges_ES
dc.publisherF. Hernández y Juan F. Madrid. Universidad de Murcia: Departamento de Biología Celular e Histologíaes_ES
dc.rightsinfo:eu-repo/semantics/openAccesses_ES
dc.rightsAttribution-NonCommercial-NoDerivatives 4.0 International*
dc.rights.urihttp://creativecommons.org/licenses/by-nc-nd/4.0/*
dc.subjectSchwannomases_ES
dc.subjectMPNSTes_ES
dc.subjectSenescencees_ES
dc.subjectp16INK4aes_ES
dc.subject.otherCDU::5 - Ciencias puras y naturales::57 - Biología::576 - Biología celular y subcelular. Citologíaes_ES
dc.titleSchwannomas, bening tumors with a senescent phenotypees_ES
dc.typeinfo:eu-repo/semantics/articlees_ES
Aparece en las colecciones:Vol.29, nº 6 (2014)

Ficheros en este ítem:
Fichero Descripción TamañoFormato 
Simonetti-29-721-730-2014.pdf7,83 MBAdobe PDFVista previa
Visualizar/Abrir


Este ítem está sujeto a una licencia Creative Commons Licencia Creative Commons Creative Commons