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Campo DC | Valor | Lengua/Idioma |
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dc.contributor.author | Simonetti, S. | - |
dc.contributor.author | Serrano, C. | - |
dc.contributor.author | Hernández-Losa, J. | - |
dc.contributor.author | Bagué, S. | - |
dc.contributor.author | Orellana, R. | - |
dc.contributor.author | Valverde, C. | - |
dc.contributor.author | Lleonart, M. E. | - |
dc.contributor.author | Aizpurua, M. | - |
dc.contributor.author | Carles, J. | - |
dc.contributor.author | Ramón y Cajal, S. | - |
dc.contributor.author | Romagosa, C. | - |
dc.date.accessioned | 2019-07-09T14:17:36Z | - |
dc.date.available | 2019-07-09T14:17:36Z | - |
dc.date.issued | 2014 | - |
dc.identifier.citation | Histology and Histopathology, vol. 29, nº 6, (2014) | es |
dc.identifier.issn | 1699-5848 | - |
dc.identifier.issn | 0213-3911 | - |
dc.identifier.uri | http://hdl.handle.net/10201/73487 | - |
dc.description.abstract | Background: Schwannomas are benign nerve sheath tumors that only very rarely undergo malignant changes. Oncogenic-induced senescence is a defense mechanism against such malignant transformation. Different molecular pathways are involved in this process, such as RAS-RAF-MAPK. Based on the fact that the RAS-RAF-MAPK pathway is known to be activated in peripheral nerve sheath tumors, this study analyzes senescence markers in Schwannomas to demonstrate the possible role of senescence in their genesis. Methods: A retrospective immunohistochemical study was done in 39 schwannoma and 18 malignant peripheral nerve sheath tumors (MPNST). Staining for p16INK4a, Ki67, p53 and CyclinD1 was performed in all the cases. Additionally, ß-galactosidase staining was done in those cases in which frozen tissue was available (n=8). Results: Higher levels of p16INK4a (p=0.0001) and lower levels of Ki67 (p=0.0001) were found in Schwannomas. Beta-galactosidase activity was positive in 5/5 Schwannomas and negative in 3/3 MPNST. Conclusions: Our results support the senescence nature of Schwannomas and the absence of a senescence phenotype in MPNST. | es |
dc.format | application/pdf | es |
dc.format.extent | 10 | es |
dc.language | eng | es |
dc.publisher | F. Hernández y Juan F. Madrid. Universidad de Murcia: Departamento de Biología Celular e Histología | es |
dc.rights | info:eu-repo/semantics/openAccess | es |
dc.rights | Attribution-NonCommercial-NoDerivatives 4.0 International | * |
dc.rights.uri | http://creativecommons.org/licenses/by-nc-nd/4.0/ | * |
dc.subject | Schwannomas | es |
dc.subject | MPNST | es |
dc.subject | Senescence | es |
dc.subject | p16INK4a | es |
dc.subject.other | CDU::5 - Ciencias puras y naturales::57 - Biología::576 - Biología celular y subcelular. Citología | es |
dc.title | Schwannomas, bening tumors with a senescent phenotype | es |
dc.type | info:eu-repo/semantics/article | es |
Aparece en las colecciones: | Vol.29, nº 6 (2014) |
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Simonetti-29-721-730-2014.pdf | 7,83 MB | Adobe PDF | Visualizar/Abrir |
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