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Campo DC | Valor | Lengua/Idioma |
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dc.contributor.author | Tabata, Chihiro | - |
dc.contributor.author | Hongo, Hiromi | - |
dc.contributor.author | Sasaki, Muneteru | - |
dc.contributor.author | Hasegawa, Tomoka | - |
dc.contributor.author | Luiz de Freitas, Paulo Henrique | - |
dc.contributor.author | Yamada, Tamaki | - |
dc.contributor.author | Yamamoto, Tomomaya | - |
dc.contributor.author | Suzuki, Reiko | - |
dc.contributor.author | Yamamoto, Tsuneyuki | - |
dc.contributor.author | Oda, Kimimitsu | - |
dc.contributor.author | Li, Minqi | - |
dc.contributor.author | Kudo, Akira | - |
dc.contributor.author | Iida, Junichiro | - |
dc.contributor.author | Amizuka, Norio | - |
dc.date.accessioned | 2019-07-09T14:40:23Z | - |
dc.date.available | 2019-07-09T14:40:23Z | - |
dc.date.issued | 2014 | - |
dc.identifier.citation | Histology and Histopathology, vol. 29, nº 6, (2014) | es |
dc.identifier.issn | 1699-5848 | - |
dc.identifier.issn | 0213-3911 | - |
dc.identifier.uri | http://hdl.handle.net/10201/73471 | - |
dc.description.abstract | Verifying whether periostin affects the distribution of type I collagen, fibronectin and tenascin C in the periodontal ligament (PDL) is important to contribute to a more thorough understanding of that protein’s functions. In this study, we have histologically examined incisor PDL of mandibles in 20 week-old male wild-type and periostin-deficient (periostin-/-) mice, by means of type I collagen, fibronectin, tenascin C, proliferating cell nuclear antigen, matrix metalloproteinase (MMP)-1 and F4/80-positive monocyte/ macrophage immunostaining, transmission electron microscopy and quantitative analysis of cell proliferation. Wild-type PDL featured well-arranged layers of collagen bundles intertwined with PDL cells, whose longitudinal axis ran parallel to the collagen fibers. However, cells in the periostin-/- PDL were irregularly distributed among collagen fibrils, which were also haphazardly arranged. Type I collagen and fibronectin reactivity was seen throughout the wild-type PDL, while in the periostin-/- PDL, only focal, uneven staining for these proteins could be seen. Similarly, tenascin C staining was evenly distributed in the wildtype PDL, but hardly seen in the periostin-/- PDL. MMP1 immunoreactivity was uniformly distributed in the wild-type PDL, but only dotted staining could be discerned in the periostin-/- PDL. F4/80-positive monocyte/macrophages were found midway between tooth- and bone-related regions in the wild-type PDL, a pattern that could not be observed in the periostin-/- PDL. In summary, periostin deficiency may not only cause PDL collagen fibril disorganization, but could also affect the distribution of other major extracellular matrix proteins such as fibronectin and tenascin C. | es |
dc.format | application/pdf | es |
dc.format.extent | 12 | es |
dc.language | eng | es |
dc.publisher | F. Hernández y Juan F. Madrid. Universidad de Murcia: Departamento de Biología Celular e Histología | es |
dc.rights | info:eu-repo/semantics/openAccess | es |
dc.rights | Attribution-NonCommercial-NoDerivatives 4.0 International | * |
dc.rights.uri | http://creativecommons.org/licenses/by-nc-nd/4.0/ | * |
dc.subject | Periostin | es |
dc.subject | Periodontal ligament | es |
dc.subject | Fibronectin | es |
dc.subject | Tenascin C | es |
dc.subject.other | CDU::5 - Ciencias puras y naturales::57 - Biología::576 - Biología celular y subcelular. Citología | es |
dc.title | Altered distribution of extracellular matrix proteins in the periodontal ligament of periostin-deficient mice | es |
dc.type | info:eu-repo/semantics/article | es |
Aparece en las colecciones: | Vol.29, nº 6 (2014) |
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