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dc.contributor.authorHejmej, Anna-
dc.contributor.authorBilinska, Barbara-
dc.date.accessioned2019-06-12T14:05:29Z-
dc.date.available2019-06-12T14:05:29Z-
dc.date.issued2014-
dc.identifier.citationHistology and Histopathology, Vol. 29, nº 7 (2014)es
dc.identifier.issn1699-5848-
dc.identifier.issn0213-3911-
dc.identifier.urihttp://hdl.handle.net/10201/71982-
dc.description.abstractMale sexual development and male reproductive functions are dependent on the normal action of androgens, and an unbalanced ratio of the active androgens can lead to varying degrees of structural and functional abnormalities within the reproductive organs. Endocrine balance can be disturbed by environmental and pharmaceutical anti-androgens (i.e. vinclozolin, phthalates, procymidone, and flutamide) that antagonize normal androgen action. Such chemical compounds enter the cell, bind to the receptor and inactivate transcription leading to disruption of androgen-mediated signaling. Assembling and functioning of cell junctions in hormone-dependent tissues, such as testis, epididymis and prostate appeared to be controlled by steroid hormones, predominantly by androgens. This review presents recent findings on the tight junction proteins mainly responsible for normal functioning of the barrier within the testis, epididymis and prostate, anchoring junction proteins that play a crucial role in normal cell-cell adhesion, and gap junction proteins through which intercellular communication takes place in the male reproductive tract. The review gives examples of animal models that are used in endocrine disruption studies with a focus on the author’s own data from studies in the pig.es
dc.formatapplication/pdfes
dc.format.extent16es
dc.languageenges
dc.publisherF. Hernández y Juan F. Madrid. Universidad de Murcia. Departamento de Biología Celular e Histologíaes
dc.rightsinfo:eu-repo/semantics/openAccesses
dc.rightsAttribution-NonCommercial-NoDerivatives 4.0 International*
dc.rights.urihttp://creativecommons.org/licenses/by-nc-nd/4.0/*
dc.subjectIntercellular junction proteinses
dc.subjectTestises
dc.subjectEpididymises
dc.subjectProstatees
dc.subject.otherCDU::6 - Ciencias aplicadas::61 - Medicinaes
dc.titleA role of junction-mediated interactions in cells of the male reproductive tract: Impact of prenatal, neonatal, and prepubertal exposure to anti-androgens on adult reproductiones
dc.typeinfo:eu-repo/semantics/articlees
Aparece en las colecciones:Vol.29, nº 7 (2014)

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