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Título: | Grow2: The HIF system, energy homeostasis and the cell cycle |
Fecha de publicación: | 2014 |
Editorial: | F. Hernández y Juan F. Madrid. Universidad de Murcia: Departamento de Biología Celular e Histología |
Cita bibliográfica: | Histology and Histopathology, vol. 29, nº 5, (2014) |
ISSN: | 1699-5848 0213-3911 |
Materias relacionadas: | CDU::6 - Ciencias aplicadas::61 - MedicinaJORNADAS PARA LA PROTECCIÓN Y DEFENSA DEL PATRIMONIO CULTURAL |
Palabras clave: | Hypoxia HIF-system Energy homeostasis |
Resumen: | Cell cycle progression is an energy demanding process and requires fine-tuned metabolic regulation. Cells must overcome an energy restriction checkpoint before becoming committed to progress through the cell cycle. Aerobic organisms need oxygen for the metabolic conversion of nutrients into energy. As such, environmental oxygen is a critical signalling molecule regulating cell fate. The Hypoxia Inducible Factors (HIFs) are a family of transcription factors that respond to changes in environmental oxygen and cell energy and coordinate a transcriptional program which forms an important part of the cellular response to a hostile environment. A significant proportion of HIFdependent transcriptional target genes, code for proteins that are involved in energy homeostasis. In this review we discuss the role of the HIF system in the regulation of energy homeostasis in response to changes in environmental oxygen and the impact on cell cycle control, and address the implications of the deregulation of this effect in cancer. |
Autor/es principal/es: | Moniz, Sónia Biddlestone, John Rocha, Sónia |
URI: | http://hdl.handle.net/10201/68603 |
Tipo de documento: | info:eu-repo/semantics/article |
Número páginas / Extensión: | 12 |
Derechos: | info:eu-repo/semantics/openAccess |
Aparece en las colecciones: | Vol.29, nº 5 (2014) |
Ficheros en este ítem:
Fichero | Descripción | Tamaño | Formato | |
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Moniz-29-589-600-2014.pdf | 2,91 MB | Adobe PDF | Visualizar/Abrir |
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