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Título: Infection through structured polymicrobial Gardnerella biofilms (StPM-GB)
Fecha de publicación: 2014
Editorial: F. Hernández y Juan F. Madrid. Universidad de Murcia: Departamento de Biología Celular e Histología
Cita bibliográfica: Histology and Histopathology, vol. 29, nº 5, (2014)
ISSN: 1699-5848
Materias relacionadas: CDU::6 - Ciencias aplicadas::61 - Medicina
Palabras clave: Bacterial vaginosis
Structured polymicrobial Gardnerella dominated bacterial biofilm
Antibiotic resistance
Resumen: BACKGROUND: We analysed data on bacterial vaginosis (BV) contradicting the paradigm of mono-infection. METHODOLOGY: Tissues and epithelial cells of vagina, uterus, fallopian tubes and perianal region were investigated using fluorescence in situ hybridization (FISH) in women with BV and controls. RESULTS: Healthy vagina was free of biofilms. Prolific structured polymicrobial (StPM) Gardnerella-dominated biofilm characterised BV. The intact StPM-Gardnerellabiofilm enveloped desquamated vaginal/prepuce epithelial cells and was secreted with urine and sperma. The disease involved both genders and occurred in pairs. Children born to women with BV were negative. Monotherapy with metronidazole, moxifloxacin or local antiseptics suppressed but often did not eradicate StPMGardnerella-biofilms. There was no BV without Gardnerella, but Gardnerella was not BV. Outside of StPM-biofilm, Gardnerella was also found in a subset of children and healthy adults, but was dispersed, temporal and did not transform into StPM-Gardnerella-biofilm. CONCLUSIONS: StPM-Gardnerella-biofilm is an infectious subject. The assembly of single players to StPM-Gardnerella-biofilm is a not trivial every day process, but probably an evolutionary event with a long history of growth, propagation and selection for viability and ability to reshape the environment. The evolutionary memory is cemented in the structural differentiation of StPM-Gardnerella-biofilms and imparts them to resist previous and emerging challenge
Autor/es principal/es: Swidsinsk, Alexander
Loening-Baucke, Vera
Mendling, Werner
Dörffel, Yvonne
Schilling, Johannes Schilling
Halwani, Zaher
Jiang, Xue-feng
Verstraelen, Hans
Swidsinski, Sonja
URI: http://hdl.handle.net/10201/68601
Tipo de documento: info:eu-repo/semantics/article
Número páginas / Extensión: 21
Derechos: info:eu-repo/semantics/openAccess
Aparece en las colecciones:Vol.29, nº 5 (2014)

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