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Campo DC | Valor | Lengua/Idioma |
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dc.contributor.author | García-Fernández, R.A. | - |
dc.contributor.author | García-Palencia, P. | - |
dc.contributor.author | Suárez, C. | - |
dc.contributor.author | Sánchez, M.A. | - |
dc.contributor.author | Gil-Gómez, G. | - |
dc.contributor.author | Sánchez, B. | - |
dc.contributor.author | Rollán, E. | - |
dc.contributor.author | Martín-Caballero, J. | - |
dc.contributor.author | Flores, J.M. | - |
dc.date.accessioned | 2019-02-05T15:19:32Z | - |
dc.date.available | 2019-02-05T15:19:32Z | - |
dc.date.issued | 2014 | - |
dc.identifier.citation | Histology and Histopathology, vol. 29, nº 3 (2014) | es |
dc.identifier.issn | 1699-5848 | - |
dc.identifier.issn | 0213-3911 | - |
dc.identifier.uri | http://hdl.handle.net/10201/67240 | - |
dc.description.abstract | Cellular senescence has been considered a novel target for cancer therapy. It has also been pointed out that p21cip1/waf1 and p27kip1 cyclin-dependent kinase inhibitors (CKIs) play a role in cellular senescence in some tumor types. Therefore, in order to address the possibility of a cooperative role between p21 and p27 proteins in senescence in vivo we analyzed cellular senescence in spontaneous glandular proliferative lesions (adrenal, thyroid and pituitary glands) in a double-KO mice model, using γH2AX, p53, p16, PTEN and Ki67 as senescence markers. The results obtained showed that p21p27 double-null mice had the lowest number of γH2AX positive cells in glandular hyperplasias and benign tumors. Also, in this group, Ki67 proliferation index correlated with a lower immunohistochemical expression of γH2AX and p53. The expression of p16 and PTEN do not seem to cause synergism of senescence in the benign lesions analyzed in p21p27 double-KO mice. These observations suggest an intrinsic cooperation between p21 and p27 CKIs in the activation of stress-induced cellular senescence and tumor progression in vivo, which would be a physiological mechanism to prevent tumor cell proliferation. | es |
dc.format | application/pdf | es |
dc.format.extent | 10 | es |
dc.language | eng | es |
dc.publisher | F. Hernández y Juan F. Madrid. Universidad de Murcia. Departamento de Biología Celular e Histología | es |
dc.rights | info:eu-repo/semantics/openAccess | es |
dc.subject | Animal model | es |
dc.subject | Hyperplasia | es |
dc.subject.other | CDU::5 - Ciencias puras y naturales::57 - Biología::576 - Biología celular y subcelular. Citología | es |
dc.title | Cooperative role between p21cip1/waf1 and p27kip1 in premature senescence in glandular proliferative lesions in mice | es |
dc.type | info:eu-repo/semantics/article | es |
Aparece en las colecciones: | Vol.29, nº 3 (2014) |
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Garcia-Fernandez-29-397-406-2014.pdf | 4,71 MB | Adobe PDF | Visualizar/Abrir |
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