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dc.contributor.authorNannini, Margherita-
dc.contributor.authorBiasco, Guido-
dc.contributor.authorAstolfi, Annalisa-
dc.contributor.authorUrbini, Milena-
dc.contributor.authorPantaleo, Maria A.-
dc.identifier.citationHistology and Histopathology, vol. 29, nº 2 (2014)es_ES
dc.description.abstractIn the last decades, the concept that Insulin-like Growth Factor (IGF) axis plays a key role in several steps of tumorigenesis, cancer growth and metastasis has been widely documented. The aberration of the IGF system has been described in many kinds of tumours, providing several lines of evidence in support of IGF receptor type 1 (IGF1R) as molecular target in cancer treatment. Gastrointestinal stromal tumors (GIST) are the most common mesenchymal tumor of the gastrointestinal tract, commonly characterized in most cases by KIT and PDGFRA gain mutations. Beyond to the well recognized KIT and PDGFRA gain mutations, in the last years other molecular aberrations have been investigated. Recently, several lines of evidence about the involvement of the IGF system in GIST have been accumulated. The aim of this review is to report all current data about the IGF system involvement in GIST, focusing on the current clinical implication and future perspectives.es_ES
dc.publisherF. Hernández y Juan F. Madrid. Universidad de Murcia. Departamento de Biología Celular e Histologíaes_ES
dc.subjectGastrointestinal stromal tumores_ES
dc.subjectInsulin growth factor receptor 1 (IGF1R)es_ES
dc.subject.otherCDU::5 - Ciencias puras y naturales::57 - Biología::576 - Biología celular y subcelular. Citologíaes_ES
dc.titleInsulin-like Growth Factor (IGF) system and gastrointestinal stromal tumours (GIST): present and futurees_ES
Appears in Collections:Vol.29, nº 2 (2014)

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