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http://hdl.handle.net/10201/65300
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Campo DC | Valor | Lengua/Idioma |
---|---|---|
dc.contributor.author | Losi, Lorena | - |
dc.contributor.author | Grande, Alexis | - |
dc.date.accessioned | 2018-12-12T12:25:30Z | - |
dc.date.available | 2018-12-12T12:25:30Z | - |
dc.date.issued | 2014 | - |
dc.identifier.citation | Histol Histopathol, vol. 29, nº 1, (2014) | es |
dc.identifier.issn | 1699-5848 | - |
dc.identifier.issn | 0213-3911 | - |
dc.identifier.uri | http://hdl.handle.net/10201/65300 | - |
dc.description.abstract | Summary. Cell-cell adhesion is a fundamental activity to allow the maintenance of epithelial integrity, and defects impairing this process promote the formation of tumors such as colorectal cancer (CRC). In this regard, a crucial role is played by adhesion molecules, named cadherins, which exert their function through the inhibition of the ß-catenin signaling proliferation pathway, constitutively activated in CRC. A number of reports, published over the last decade, have highlighted the existence of a novel cadherin family member, called µ-protocadherin, to underline the hybrid nature of its extra-cellular region, including both cadherin-like and mucin-like domains. Is has been shown that this protein plays an important role in inter-cellular adhesion processes, inhibits ß-catenin activity in normal colorectal mucosa, undergoes a down-regulated expression in CRC and is up-regulated upon treatm | es |
dc.format | application/pdf | es |
dc.format.extent | 9 | es |
dc.language | eng | es |
dc.publisher | F. Hernández y Juan F. Madrid. Universidad de Murcia: Departamento de Biología Celular e Histología | es |
dc.rights | info:eu-repo/semantics/openAccess | es |
dc.subject | µ-protocadherin | es |
dc.subject | MUCDHL | es |
dc.subject | ß-catenin | es |
dc.subject.other | CDU::6 - Ciencias aplicadas::61 - Medicina | es |
dc.title | Involvement of µ-protocadherin in colorectal carcinogenesis: a promise for clinico-pathological evaluation | es |
dc.type | info:eu-repo/semantics/article | es |
Aparece en las colecciones: | Vol.29, nº 1 (2014) |
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Losi-29-11-19-2014.pdf | 160,66 kB | Adobe PDF | ![]() Visualizar/Abrir |
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