Please use this identifier to cite or link to this item: http://hdl.handle.net/10201/60901

Title: Differences in collagen distribution of healthy and regenerated periodontium. Histomorphometric study in dogs
Issue Date: 2013
Publisher: F. Hernández y Juan F. Madrid. Universidad de Murcia. Departamento de Biología Celular e Histología
Citation: Histology and Histopathology, vol. 28, nº 10 (2013)
ISSN: 1699-5848
0213-3911
Related subjects: CDU::5 - Ciencias puras y naturales::57 - Biología::576 - Biología celular y subcelular. Citología
Keywords: Periodontal regeneration
Collagen
Abstract: Previous studies have shown that there is a relationship between periodontal disease and the distribution of collagen fibers. This study evaluated the distribution of collagen types I and III in regenerated bone and periodontal ligament, comparing them to the tissues near the regenerated area and to the healthy periodontium. In the third (P3) and fourth (P4) mandibular premolars of 5 healthy mongrel dogs, bilaterally, buccal class 2 furcation lesions were surgically created and chronified for 3 weeks. After that, full flaps were elevated and expanded polytetrafluoroethylene (e-PTFE) membranes were adapted, sutured and recovered by the flaps. Two weeks after surgery, two membranes on the same side were removed and the other membranes were removed four weeks after surgery. The dogs were euthanized at 12 weeks following placement of the e-PTFE membranes. P3 and P4 teeth as well as the second premolars (healthy control teeth) and their periodontal tissues were removed and histologically processed for Collagen Quantification (COLQ). The amount of type III collagen was higher in native bone compared to the regenerated area. For periodontal ligament, COLQ for type I collagen showed statistically significant differences (Tukeys’s Multiple Comparison, p<0.05) between the regenerated groups and the control group. These differences were not found for type III COLQ. There are significant differences in collagen distribution among the regenerated, native and control tissues. Membrane removal 2 or 4 weeks postoperatively did not influence the collagen composition.
Primary author: Souza, Sérgio Luis Scombatti de
Macedo, Guilherme O.
Silveira e Souza, Adriana M.M.
Taba Jr, Mário
Novaes Jr, Arthur B.
Oliver, Constance
Jamur, Maria C.
Correa, Vani M.A.
URI: http://hdl.handle.net/10201/60901
Document type: info:eu-repo/semantics/article
Number of pages / Extensions: 10
Rights: info:eu-repo/semantics/openAccess
Appears in Collections:Vol.28, nº10 (2013)

Files in This Item:
File Description SizeFormat 
Souza-28-1315-1324-2013.pdf31,03 MBAdobe PDFView/Open


This item is licensed under a Creative Commons License Creative Commons