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Título: A comprehensive morphometric analysis of the internal thoracic artery with emphasis on age, gender and left-to-right specific differences
Fecha de publicación: 2013
Editorial: F. Hernández y Juan F. Madrid. Universidad de Murcia. Departamento de Biología Celular e Histología
Cita bibliográfica: Histology and Histopathology, vol. 28, nº 10 (2013)
ISSN: 1699-5848
0213-3911
Materias relacionadas: CDU::6 - Ciencias aplicadas::61 - Medicina::616 - Patología. Medicina clínica. Oncología::616.1 - Patología del sistema circulatorio, de los vasos sanguíneos. Transtornos cardiovasculares
CDU::5 - Ciencias puras y naturales::57 - Biología::576 - Biología celular y subcelular. Citología
Palabras clave: Internal thoracic artery
Morphometry
Resumen: Aims of the study. The aim of this analysis was the morphometric description of the internal thoracic artery (ITA) with an emphasis on age, gender and left-to-right specific differences, as well as on age and atherosclerosis related changes of the elastic skeleton. Methods. Forty eight arteries were obtained during forensic autopsies from 32 persons who had died of non-vascular causes. The following morphometric parameters were analyzed: thickness of the intima, the medial layer and the wall, the intima-to-media ratio and the elastic skeleton parameters. Results. The intima thickness increases significantly with aging (ANOVA F=34.061, p<0.001), as does the intima-to-media ratio (ANOVA F=10.831, p<0.001). With aging, there is a significant increase in the thickness of the media (F=56.519; p<0.001) and of the wall (F=34.094; p<0,001). There is a significant increase in the media thickness during the development of atherosclerosis in the ITA (ANOVA F=11.848, p<0.001). No significant difference was found when these data were analyzed based on the left-to-right principle or depending on gender of the patients. However, the analysis of the elastic skeleton parameters indicated that the combined effects of aging, atherosclerosis and male gender lead to the degeneration of the elastic skeleton of the ITA. Conclusion. The grade of atherosclerosis gradually increases with aging as shown by morphometric analysis. The increase in the medial layer thickness suggests the potential for positive remodeling of the ITA during aging and atherosclerosis. The left/right position has no influence on morphometric parameters of the ITA, while male gender affects parameters of the elastic skeleton.
Autor/es principal/es: Labudović Borović, Milica
Borović, Saša
Marinković-Erić, Jelena
Todorović, Vera
Puškaš, Nela
Kočica, Mladen
Radak, Ðorde
Lačković, Vesna
URI: http://hdl.handle.net/10201/60865
Tipo de documento: info:eu-repo/semantics/article
Número páginas / Extensión: 16
Derechos: info:eu-repo/semantics/openAccess
Aparece en las colecciones:Vol.28, nº10 (2013)

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