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dc.contributor.authorLeonardi, Rosalia-
dc.contributor.authorMatthews, J.B.-
dc.contributor.authorLoreto, Carla-
dc.contributor.authorMusumeci, Giuseppe-
dc.contributor.authorCampisi, G.-
dc.contributor.authorLo Muzio, L.-
dc.contributor.authorDos Santos, J.N.-
dc.contributor.authorPastorino, L.-
dc.contributor.authorBufo, P.-
dc.contributor.authorPannone, G.-
dc.date.accessioned2018-07-16T11:00:40Z-
dc.date.available2018-07-16T11:00:40Z-
dc.date.issued2013-
dc.identifier.citationHistology and Histopathology, vol. 28, nº 9 (2013)es
dc.identifier.issn1699-5848-
dc.identifier.issn0213-3911-
dc.identifier.urihttp://hdl.handle.net/10201/60306-
dc.description.abstractAim: To determine the epithelial expression of ß-catenin and survivin in sporadic (primary, and recurrent) and nevoid basal cell carcinoma syndrome (NBCCS) keratocystic odontogenic tumour (KCOT) in order to assess activation of the ß-catenin pathway and evidence of apoptotic inhibition, processes that may contribute to the known differences in their biological behaviour. Materials and Methods: Sections from 40 cases of KCOT (19 sporadic/primary; 9 sporadic/recurrent and 12 NBCCS-associated) were immunohistochemically stained for ß-catenin and survivin. The extent and intensity of immunoreactivity within the lining epithelium was assessed, using semi-quantitative scales, independently by two pathologists who were blinded to the clinical-pathological data. Data were analysed using Kruskal-Wallis test and, for pair-wise comparisons, Mann-Whitney test with Bonferroni correction. Results: All cystic epithelial linings stained for ß- catenin and survivin but there were differences in the pattern and intensity of staining among KCOT types. Sporadic primary KCOT showed weaker staining for ß- catenin (P=0.0003) and survivin (P<0.0048) that was restricted to the basal and para-basal layers only, compared to sporadic recurrent and NBCCS-associated KCOT, which showed expression throughout all epithelial layers. There were no differences in ß-catenin expression among recurrent and NBCCS-associated KCOT, whereas the intensity of survivin staining was higher in NBCCS-KCOT (P=0.0003). Nuclear staining for ß-catenin was found exclusively in recurrent (5/9 cases) and NBCCS-associated (4/12 cases) KCOT. Conclusion: The data demonstrate ß-catenin delocalization and survivin over-expression in recurrent sporadic and NBCCS-associated KCOT suggesting that these pathways are related to apoptotic inhibition have a role in KCOT growth and recurrence.es
dc.formatapplication/pdfes
dc.format.extent10es
dc.languageenges
dc.publisherF. Hernández y Juan F. Madrid. Universidad de Murcia. Departamento de Biología Celular e Histologíaes
dc.rightsinfo:eu-repo/semantics/openAccesses
dc.subjectNBCCSes
dc.subjectß-catenines
dc.subject.otherCDU::6 - Ciencias aplicadas::61 - Medicina::616 - Patología. Medicina clínica. Oncologíaes
dc.titleBeta-catenin and survivin expression in keratocystic odontogenic tumor (KCOT). A comparative immunohistochemical study in primary, recurrent and nevoid basal cell carcinoma syndrome (NBCCS)-associated lesionses
dc.typeinfo:eu-repo/semantics/articlees
Aparece en las colecciones:Vol.28, nº 9 (2013)

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