Por favor, use este identificador para citar o enlazar este ítem: http://hdl.handle.net/10201/59583

Título: Clinical correlations and prognostic relevance of Fn14 expression in breast carcinoma
Fecha de publicación: 2013
Editorial: F. Hernández y Juan F. Madrid. Universidad de Murcia. Departamento de Biología Celular e Histología
Cita bibliográfica: Histology and Histopathology, vol. 28, nº 7 (2013)
ISSN: 1699-5848
0213-3911
Materias relacionadas: CDU::5 - Ciencias puras y naturales::57 - Biología::576 - Biología celular y subcelular. Citología
Palabras clave: Fn14
Breast cancer
Resumen: The aim of the present study was to clarify the expression of fibroblast growth factor-inducible 14 (Fn14), a type I transmembrane protein, in breast carcinoma and its correlation with clinicopathological features. We examined the expression of Fn14 in normal breast epithelial cells as well as in breast carcinoma cells, and in 12 cases of breast carcinoma tissues and the paired normal breast tissues by RT-PCR and Western blot analysis. In addition, we analyzed Fn14 protein expression in 171 clinicopathologically characterized breast carcinoma cases by immunohistochemistry. Statistical analyses were applied to test for prognostic and diagnostic associations. The results show that the level of Fn14 mRNA and protein were higher in the cancer cell lines and most cancer tissues than in normal control tissues. Immunohistochemistry showed that Fn14 was expressed in 148 of 171 cases (86.5%). Statistical analysis of cases showed that there was a significant difference of Fn14 expression in patients categorized according to HER-2 expression, lymph node metastasis and clinical stage. Our results suggest that Fn14 protein is a valuable marker of breast carcinoma progression. Fn14 might be used as a valuable prognostic marker for breast carcinoma patients.
Autor/es principal/es: Wang, Jian
Liu, Yang
Wei, Xiao-Yi
Wang, En-Hua
URI: http://hdl.handle.net/10201/59583
Tipo de documento: info:eu-repo/semantics/article
Número páginas / Extensión: 6
Derechos: info:eu-repo/semantics/openAccess
Aparece en las colecciones:Vol.28, nº 7 (2013)

Ficheros en este ítem:
Fichero Descripción TamañoFormato 
Wang-28-859-864-2013.pdf2,04 MBAdobe PDFVista previa
Visualizar/Abrir


Este ítem está sujeto a una licencia Creative Commons Licencia Creative Commons Creative Commons