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Campo DC | Valor | Lengua/Idioma |
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dc.contributor.author | Iglesias-Linares, Alejandro | - |
dc.contributor.author | Yañez-Vico, Rosa Mª | - |
dc.contributor.author | Ballesta-Mudarra, Sofía Ballesta-Mudarra | - |
dc.contributor.author | Ortiz-Ariza, Estefanía | - |
dc.contributor.author | Mendoza-Mendoza, Asunción | - |
dc.contributor.author | Perea-Pérez, Evelio | - |
dc.contributor.author | Moreno-Fernández, Ana Mª | - |
dc.contributor.author | Solano-Reina, Enrique | - |
dc.date.accessioned | 2018-05-17T09:57:53Z | - |
dc.date.available | 2018-05-17T09:57:53Z | - |
dc.date.issued | 2013 | - |
dc.identifier.citation | Histology and Histopathology, vol. 28, nº 6. (2013) | es |
dc.identifier.issn | 1699-5848 | - |
dc.identifier.issn | 0213-3911 | - |
dc.identifier.uri | http://hdl.handle.net/10201/58484 | - |
dc.description.abstract | y. External pical root resorption (EARR) is a frequent iatrogenic problem following orthodontic treatment in endodontically-treated teeth, about which the literature reports substantial variability in postorthodontic treatment EARR responses. The main focus of the present study is to clarify whether variants in the interleukin-1 receptor antagonist gene coding for the IL1ra protein have a positive/negative influence on EARR of endodontically-treated teeth. Ninety-three orthodontic patients were genetically screened for a single nucleotide polymorphism (SNP:rs419598) in the IL1 cluster. The sample was classified into 2 groups: group 1 (affectedgroup) showed radiographic EARR of more than 2mm; group 2 (control-group), had no EARR or EARR≤ to 2mm following orthodontic treatment on root-filled teeth. Logistic regression analysis was performed to obtain an adjusted estimate between the SNPs studied and EARR. Genotype distributions, allelic frequencies, adjusted odds ratios (OR) and 95% confidence intervals were also calculated. We found that subjects homozygous [1/1(TT)] for the IL1RN gene [OR:10.85; p=0.001;CI:95%] were at risk of EARR in root-filled teeth. Genetic variants in the antagonist axis balance of the IL1RN(rs419598) have a direct repercussion on the predisposition to post-orthodontic EARR in root-filled teeth. Variants in allele 1 of the interleukin-1 receptor antagonist gene(rs419598) are associated(p=0.001**) with an increased risk of suffering post-orthodontic EARR in root-filled teeth. | es |
dc.format | application/pdf | es |
dc.format.extent | 7 | es |
dc.language | eng | es |
dc.publisher | F. Hernández y Juan F. Madrid. Universidad de Murcia: Departamento de Biología Celular e Histología | es |
dc.rights | info:eu-repo/semantics/openAccess | es |
dc.subject | External root resorption | es |
dc.subject | Interleukin 1 receptor antagonist | es |
dc.subject.other | CDU::6 - Ciencias aplicadas::61 - Medicina | es |
dc.title | Interleukin 1 receptor antagonist (IL1RN) genetic variations condition post-orthodontic external root resorption in endodontically-treated teeth | es |
dc.type | info:eu-repo/semantics/article | es |
Aparece en las colecciones: | Vol.28, nº 6 (2013) |
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Iglesias-Linares-28-767-773-2013.pdf | 239,13 kB | Adobe PDF | Visualizar/Abrir |
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