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http://hdl.handle.net/10201/58324
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Campo DC | Valor | Lengua/Idioma |
---|---|---|
dc.contributor.author | Jayasinghe, Caren | - |
dc.contributor.author | Simiantonaki, Nektaria | - |
dc.contributor.author | Kirkpatrick, James | - |
dc.date.accessioned | 2018-05-11T14:49:30Z | - |
dc.date.available | 2018-05-11T14:49:30Z | - |
dc.date.issued | 2013 | - |
dc.identifier.citation | Histology and histopathology, Vol. 28, n.º 5 (2013) | es |
dc.identifier.issn | 0213-3911 | - |
dc.identifier.issn | 1699-5848 | - |
dc.identifier.uri | http://hdl.handle.net/10201/58324 | - |
dc.description.abstract | The biological behavior of VEGF-B, a ligand of the receptor VEGFR-1, is still enigmatic. Despite its high sequence homology to the better known angiogenetic factor VEGF-A, the function of VEGF-B has remained elusive. Especially, its role in tumor biology has thus far not been defined. In the present study we address the question of whether VEGF-B could play a role in the metastatic process of colorectal carcinomas (CRC). Using immunohistochemistry we investigated its expression in the tumor tissue of 91 nonmetastatic, lymphogenous-metastatic and haematogenous-metastastic CRC. Independently of metastatic status, VEGF-B was expressed in endothelial as well as in tumor cells. 81% of the CRC showed a positive, partly focal, partly disseminated endothelial expression in intratumoral vessels and the vascular fraction throughout the invasive tumor margin. Almost all of the VEGF-B positive vessels were of blood vascular origin. Many of these were thick-walled blood vessels with atherosclerotic changes characterizing preexistent but not angiogenetic vasculature. Thus it appears that VEGF-B might be an important ligand to ensure the blood supply for tumor survival. 46% of the CRC presented an additional tumoral VEGF-B expression which significantly correlated with haematogenous metastasis (p=0.006). These morphological results provide evidence for a probable pathobiological significance of VEGF-B in the tumor progression of CRC, especially in the case of haematogenous metastasis. It appears that VEGF-B might be an important ligand in the signalling between the tumor and preexisting blood vessels to ensure a functional blood supply for tumor survival. | es |
dc.format | application/pdf | es |
dc.format.extent | 7 | es |
dc.language | eng | es |
dc.rights | info:eu-repo/semantics/openAccess | es |
dc.subject | VEGF-B | es |
dc.subject | Colorectal cancer | es |
dc.subject.other | CDU::6 - Ciencias aplicadas::61 - Medicina::616 - Patología. Medicina clínica. Oncología | es |
dc.title | VEGF-B expression in colorectal carcinomas and its relevance for tumor progression | es |
dc.type | info:eu-repo/semantics/article | es |
Aparece en las colecciones: | Vol.28, nº 5 (2013) |
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Fichero | Descripción | Tamaño | Formato | |
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Aigelsreiter-28-597-603-2013.pdf | 9,29 MB | Adobe PDF | ![]() Visualizar/Abrir |
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