Please use this identifier to cite or link to this item: http://hdl.handle.net/10201/56111

Title: Physical forces and non linear dynamics mould fractal cell shape. Quantitative morphological parameters and cell phenotype
Issue Date: 2013
Citation: Histology and histopathology,vol. 28, nº 2, (2013)
ISSN: 1699-5848
0213-3911
Related subjects: CDU::6 - Ciencias aplicadas::61 - Medicina
Keywords: Cell shape
Fractals
Abstract: Cell shape is mainly determined by biophysical constraints, interacting according to nonlinear dynamics upon the basic units provided by the genome. In turn, the specific configuration a cell acquires plays a fundamental, permissive role in modulating gene expression and many other complex biological functions. Cell shape is tightly connected to cell activity and can be considered the most critical determinant of cell function. As a consequence, measurable parameters describing shape could be considered as ‘omics’ descriptors of the specific level of observation represented by the cell-stroma system. Such an approach promises to formalize some of the underlying basic mechanisms and, ultimately, provide a holistic understanding of the biological processes.
Primary author: Bizzarri, M.
Pasqualato, A.
Cucina, A.
Pasta, V.
URI: http://hdl.handle.net/10201/56111
Document type: info:eu-repo/semantics/article
Number of pages / Extensions: 20
Rights: info:eu-repo/semantics/openAccess
Appears in Collections:Vol.28, nº 2 (2013)

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