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Título: | Evaluation of tissue response and genotoxicity of poly(L/D-lactic acid) disks implanted in rat calvarium |
Fecha de publicación: | 2012 |
Editorial: | F. Hernández y Juan F. Madrid. Universidad de Murcia. Departamento de Biología Celular e Histología |
Cita bibliográfica: | Histology and histopathology, Vol. 27, n.º 12 (2012) |
ISSN: | 1699-5848 0213-3911 |
Materias relacionadas: | CDU::6 - Ciencias aplicadas::61 - Medicina |
Palabras clave: | Bone regeneration Genotoxicity |
Resumen: | The aim of the present study was to evaluate local and cytotoxicity systemic tissue reaction in the skull of rats using the implantation of disks of poly (lactic L/D-acid) and evaluate its genotoxicity. 25 males Wistar rats were used, 20 animals underwent surgical procedures and had the discs implanted in the parietal bone, and 5 animals received postoperative medication in the same way, serving as a control group for genotoxicity. The results were subjected to statistical evaluation by analysis of variance (ANOVA). In histological evaluation, between periods of 90 and 120 days in the control group, a new formation at the edges of the defect was noticed. In the experimental group, there was new bone formation at the edges of the defect, migrating below the site occupied by the disk, an absence of inflammatory infiltrate. Regarding the evaluation of genotoxicity, a significant reduction in the frequency of polychromatic erythrocytes in relation to negative control or significant increase in the polychromatic erythrocytes with micronuclei was not detected. So, the material used in this study is biocompatible and well tolerated by the tissues studied, and found to be negative for chromosomal mutagenicity. |
Autor/es principal/es: | Gonçalves Göelze, Juliana Linard Avelar, Rafael do Nascimento Dolzan, André Emmel Becker, Otávio Haas Junior, Orion Luiz de Oliveira, Luciane Yumi Suzuki de Oliveira, Rogério Belle |
URI: | http://hdl.handle.net/10201/54479 |
Tipo de documento: | info:eu-repo/semantics/article |
Número páginas / Extensión: | 7 |
Derechos: | info:eu-repo/semantics/openAccess |
Aparece en las colecciones: | Vol.27, nº12 (2012) |
Ficheros en este ítem:
Fichero | Descripción | Tamaño | Formato | |
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Goelzer-27-1551-1557-2012.pdf | 1,94 MB | Adobe PDF | Visualizar/Abrir |
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