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Campo DC | Valor | Lengua/Idioma |
---|---|---|
dc.contributor.author | Brand, Camila | - |
dc.contributor.author | Oliveira, Felipe L. | - |
dc.contributor.author | Takiya, Christina M. | - |
dc.contributor.author | Palumbo Jr, Antonio | - |
dc.contributor.author | Hsu, Daniel K. | - |
dc.contributor.author | Liu, Fu-Tong | - |
dc.contributor.author | Borojevic, Radovan | - |
dc.contributor.author | Chammas, Roger | - |
dc.contributor.author | El-Cheikh, Márcia C. | - |
dc.date.accessioned | 2017-09-08T16:17:18Z | - |
dc.date.available | 2017-09-08T16:17:18Z | - |
dc.date.issued | 2012 | - |
dc.identifier.citation | Histology and histopathology, Vol. 27, nº 8 (2012) | es |
dc.identifier.issn | 1699-5848 | - |
dc.identifier.issn | 0213-3911 | - |
dc.identifier.uri | http://hdl.handle.net/10201/54116 | - |
dc.description.abstract | Schistosoma mansoni synthesizes glycoconjugates which interact with galectin-3, eliciting an intense humoral immune response. Moreover, it was demonstrated that galectin-3 regulates B cell differentiation into plasma cells. Splenomegaly is a hallmark event characterized by polyclonal B cell activation and enhancement of antibody production. Here, we investigated whether galectin-3 interferes with spleen organization and B cell compartment during chronic schistosomiasis, using wild type (WT) and galectin-3-/- mice. In chronically-infected galectin-3-/- mice the histological architecture of the spleen, including white and red pulps, was disturbed with heterogeneous lymphoid follicles, an increased number of plasma cells (CD19-B220-/lowCD138+) and a reduced number of macrophages (CD19-B220-Mac-1+CD138-) and B lymphocytes (CD19+B220+/highCD138-), compared with the WT infected mice. In the absence of galectin-3 there was an increase of annexin-V+PI- cells and a major presence of apoptotic cells in spleen compared with WT infected mice. In spleen of WT infected mice galectin-3 was largely expressed in lymphoid follicles and extrafollicular sites. Thus, we propose that galectin-3 plays a role in splenic architecture, controlling distinct events such as apoptosis, macrophage activity, B cell differentiation and plasmacytogenesis in the course of S. mansoni infection | es |
dc.format | application/pdf | es |
dc.format.extent | 12 | es |
dc.language | eng | es |
dc.publisher | F. Hernández y Juan F. Madrid. Universidad de Murcia. Departamento de Biología Celular e Histología | es |
dc.rights | info:eu-repo/semantics/openAccess | es |
dc.subject | Galectin-3 | es |
dc.subject | Macrophages | es |
dc.subject.other | CDU::6 - Ciencias aplicadas::61 - Medicina::616 - Patología. Medicina clínica. Oncología | es |
dc.title | The involvement of the spleen during chronic phase of Schistosoma mansoni infection in galectin-3-/- mice | es |
dc.type | info:eu-repo/semantics/article | es |
Aparece en las colecciones: | Vol.27, nº 8 (2012) |
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Brand-27-1109-1120-2012.pdf | 28,93 MB | Adobe PDF | Visualizar/Abrir |
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