Please use this identifier to cite or link to this item: http://hdl.handle.net/10201/54081

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dc.contributor.authorPark, Stanley-
dc.contributor.authorChan, Chi-Chao-
dc.date.accessioned2017-09-07T17:55:38Z-
dc.date.available2017-09-07T17:55:38Z-
dc.date.issued2012-
dc.identifier.citationHistology and histopathology, Vol. 27, nº 8 (2012)es_ES
dc.identifier.issn1699-5848-
dc.identifier.issn0213-3911-
dc.identifier.urihttp://hdl.handle.net/10201/54081-
dc.description.abstractVon Hippel-Lindau (VHL) disease is a highly penetrant autosomal dominant systemic malignancy that gives rise to cystic and highly vascularized tumors in a constellation of organs. Patients with VHL disease commonly present with hemangioblastomas in the central nervous system and the eye while other manifestations include pheochromocytoma, clear cell renal cell carcinoma, endolymphatic sac tumors of the middle ear, pancreatic cystadenomas, epididymal and broad ligament cystadenomas. Animal models inactivating the VHL gene product in various organ tissues have been constructed over the past 15 years to parse its HIF-associated mechanisms and its link to tumorigenesis. These models, despite advancing our understanding the molecular role of VHL, are by and large unable to recapitulate the more common features of human VHL disease. Up to date, no model exists that develop retinal hemangioblastomas, the most common clinical manifestation. The purpose of this review is: (1) to discuss the need for an ocular VHL model, (2) to review the animal models that recapitulate clinical VHL disease and (3) to propose potential mechanisms of tumorigenesis for the development of ocular VHLes_ES
dc.formatapplication/pdfes_ES
dc.format.extent10es_ES
dc.languageenges_ES
dc.publisherF. Hernández y Juan F. Madrid. Universidad de Murcia. Departamento de Biología Celular e Histologíaes_ES
dc.rightsinfo:eu-repo/semantics/openAccesses_ES
dc.subjectRetinal hemangio-blastomaes_ES
dc.subjectAnimal modeles_ES
dc.subject.otherCDU::6 - Ciencias aplicadas::61 - Medicina::616 - Patología. Medicina clínica. Oncologíaes_ES
dc.titleVon Hippel-Lindau Disease (VHL): A need for a murine model with retinal hemangioblastomaes_ES
dc.typeinfo:eu-repo/semantics/articlees_ES
Appears in Collections:Vol.27, nº 8 (2012)

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