Por favor, use este identificador para citar o enlazar este ítem: http://hdl.handle.net/10201/54075

Registro completo de metadatos
Campo DCValorLengua/Idioma
dc.contributor.authorBocanegra, Victoria-
dc.contributor.authorRinaldi Tosi, Martín-
dc.contributor.authorGil Lorenzo, Andrea-
dc.contributor.authorCacciamani, Valeria-
dc.contributor.authorManucha, Walter-
dc.contributor.authorFornés, Miguel-
dc.contributor.authorVallés, Patricia C.-
dc.date.accessioned2017-09-07T15:23:59Z-
dc.date.available2017-09-07T15:23:59Z-
dc.date.issued2012-
dc.identifier.citationHistology and histopathology, Vol. 27, nº 7 (2012)es_ES
dc.identifier.issn1699-5848-
dc.identifier.issn0213-3911-
dc.identifier.urihttp://hdl.handle.net/10201/54075-
dc.description.abstractIntrarenal renin-Angiotensin system (RAS) activity is increased during early development and is further enhanced by unilateral ureteral obstruction (UUO). We studied the involvement of mitogen-activated protein (MAP) kinase members and the RhoA GTPase signaling pathways on the regulation of renal cell response after AT1 Angiotensin II receptor inhibition in obstruction. Neonatal rats subjected to sham operation or complete UUO within the first 48 hours of life received saline vehicle, Losartan (AT1 inhibitor), or PD-123319 (AT2 inhibitor) during the first 14 days of life. Cortex tubular epithelial cell apoptotic response was shown by TUNEL and confirmed by electron microscopy associated with mitochondrial signaling pathway through the increased proapoptotic ratio Bax/BcL-2, and consequently increased caspase 3 expression and activity in obstructed kidney before and after Type 1 (AT1) receptor blockade. Non injury of contralateral kidney was shown. The convergence of two independent signal pathways, the RhoA GTPase and pERK and concurrent inhibition of JNK MAP kinase, were required for the apoptotic response in 14 day kidney obstructed tubular cells either with or without Losartan treatment. Absence of increased AT2 protein expression after AT1 receptor inhibition on day 14 of obstruction was shown. Selective AngiotensinAT2-receptor inhibition with PD-123319 had no protective effect on the renal response to complete 14 day UUO. We suggest a role of both RhoA GTPase activation and the opposing actions of the ERK and JNK-MAP kinase signaling pathways as events involved in tubular cell apoptosis regulation in neonatal UUO. The selective AT1-receptor inhibition had no effect on the renal cellular response in the kidney subjected to UUO for 14 days.es_ES
dc.formatapplication/pdfes_ES
dc.format.extent12es_ES
dc.languageenges_ES
dc.publisherF. Hernández y Juan F. Madrid. Universidad de Murcia. Departamento de Biología Celular e Histologíaes_ES
dc.rightsinfo:eu-repo/semantics/openAccesses_ES
dc.subjectApoptosises_ES
dc.subject.otherCDU::6 - Ciencias aplicadas::61 - Medicina::616 - Patología. Medicina clínica. Oncologíaes_ES
dc.titleAngiotensin AT1 receptor inhibition-induced apoptosis by RhoA GTPase activation and pERK1/2 signaling pathways in neonatal obstructive nephropathyes_ES
dc.typeinfo:eu-repo/semantics/articlees_ES
Aparece en las colecciones:Vol.27, nº 7 (2012)

Ficheros en este ítem:
Fichero Descripción TamañoFormato 
Bocanegra-27-919-930-2012.pdf2,71 MBAdobe PDFVista previa
Visualizar/Abrir


Este ítem está sujeto a una licencia Creative Commons Licencia Creative Commons Creative Commons