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Título: Extracellular matrix, biotensegrity and tumor microenvironment. An update and overview
Fecha de publicación: 2012
Editorial: F. Hernandez y JuanF. Madrid. Universidad de Murcia. Departamento de Biología Celular e Histología.
Cita bibliográfica: Histology and Histopatholy, Volume 27, number 6 (June), 2012
ISSN: 1699-5848
0213-3911
Materias relacionadas: CDU::5 - Ciencias puras y naturales::57 - Biología
Palabras clave: Extracellular matrix
Tensegrity
Resumen: The extracellular matrix (ECM) constitutes a three-dimensional network that surrounds all cells, organs and tissues in the body. It forms a biophysical filter for protection, nutrition and cell innervation, as well as the medium for facilitating immune response, angiogenesis, fibrosis and tissue regeneration. It is the mechanism by which mechanical forces are transmitted to the basement membrane which, through the integrins, supports the tensegrity system and activates the epigenetic mechanisms of the cell. A review and update on current knowledge on this topic reveals how disturbance of the ECM leads to a loss of efficient filtering, nutrition, elimination, and cell denervation functions, in addition to loss of regeneration capacity and disorders in mechanotransduction. Furthermore, such disturbance results in a loss of substrate, and with it the ability to provide a proper immune response against tumor, toxic and infectious agents. Reciprocal communication between ECM stromal and parenchymatous cells directs gene expression. The oncogenic capacity of the stroma derives from the associated cells as well as from the tumor cells, the angiogenic microenvironment and from an alteration in tensegrity; all of which are dependent on the ECM. It has been shown that the malignant phenotype is reversible by correction of the altered cues of the ECM.
Autor/es principal/es: Noguera, Rosa
Nieto, Olga Alicia
Tadeo, Irene
Fariñas, Fernando
Álvaro, Tomás
URI: http://hdl.handle.net/10201/52444
Tipo de documento: info:eu-repo/semantics/article
Número páginas / Extensión: 13
Derechos: info:eu-repo/semantics/openAccess
Aparece en las colecciones:Vol.27, nº 6 (2012)

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