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Título: | Peroxisome morphology in pathology |
Fecha de publicación: | 2012 |
Editorial: | F. Hernandez y JuanF. Madrid. Universidad de Murcia. Departamento de Biología Celular e Histología. |
Cita bibliográfica: | Histology and Histopatholy, Volume 27, number 6 (June), 2012 |
ISSN: | 1699-5848 0213-3911 |
Materias relacionadas: | CDU::5 - Ciencias puras y naturales::57 - Biología |
Palabras clave: | Peroxisomes Organelle dynamics |
Resumen: | Summary. Peroxisomes are remarkably dynamic and versatile organelles that are essential for human health and development. They respond to physiological changes in the cellular environment by adapting their morphology, number, enzyme content and metabolic functions accordingly. With the discovery of the first key peroxisomal morphology proteins, the investigation of peroxisomal shape, distribution and dynamics has become an exciting new field in cell biology and biomedical sciences because of its relation to organelle functionality and its impact on developmental and physiological processes. In this review, we summarize recent findings on peroxisome biology, dynamics and the modulation of peroxisome morphology, especially in mammals. Furthermore, we discuss the roles of peroxisome dynamics and morphology in cell pathology and present recent examples for alterations in peroxisome morphology under disease conditions. Besides defects in the peroxisomal morphology machinery, we also address peroxisome biogenesis disorders, alterations of peroxisome number during carcinogenesis and liver cirrhosis, and morphological alterations of peroxisomes during viral infection. |
Autor/es principal/es: | Ribeiro, Daniela Castro, Inês Fahimi, H. Dariush Schrader, Michael |
URI: | http://hdl.handle.net/10201/52440 |
Tipo de documento: | info:eu-repo/semantics/article |
Número páginas / Extensión: | 16 |
Derechos: | info:eu-repo/semantics/openAccess |
Aparece en las colecciones: | Vol.27, nº 6 (2012) |
Ficheros en este ítem:
Fichero | Descripción | Tamaño | Formato | |
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Ribeiro-27-661-676-2012.pdf | 886,66 kB | Adobe PDF | Visualizar/Abrir |
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