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Título: | Visualizing TGF-ß and BMP signaling in human atherosclerosis: a histological evaluation based on Smad activation |
Fecha de publicación: | 2012 |
Editorial: | F. Hernandez y JuanF. Madrid. Universidad de Murcia. Departamento de Biología Celular e Histología. |
Cita bibliográfica: | Histology and Histopatholgy. Volume 27, number 3 (March), 2012 |
ISSN: | 1699-5848 0213-3911 |
Materias relacionadas: | CDU::5 - Ciencias puras y naturales::57 - Biología |
Palabras clave: | Atherosclerosis Aorta |
Resumen: | Background: The TGF-ß superfamily members Transforming Growth Factor-ß (TGF-ß/Activin) and Bone Morphogenetic Proteins (BMP) have been implicated in the pathogenesis of atherosclerosis. However, their role in human disease remains controversial. In this study we used Smad phosphorylation as a read out for TGF-ß and BMP signaling during the initiation, progression and (de)stabilization of human atherosclerotic disease. Material and methods: A systematic analysis was performed in 114 peri-renal aortic patches (stained with Movat Pentachrome, H&E, pSmad2, pSmad1,5,8 and PAI-1) covering the entire atherosclerotic spectrum (van Dijk, 2010). Immunostaining against T-cells (CD3) and monocytes and macrophages (CD68) was used to explore a putative association between TGF-ß and BMP signaling and vascular inflammation. Results: Smad phosphorylation was present within the normal arterial wall in approximately 10% of the endothelial cells and intimal smooth muscle cells. A significant increase in pSmad2 and pSmad1,5,8 positivity was found in non-progressive lesions (>50% positivity). No further increase or decrease was found in the progressive atherosclerotic lesions, vulnerable and stabilized lesions. No association was found between TGF-ß and BMP signaling and CD3 and CD68 expression, nor cap thickness. Conclusion: Activation of the TGF-ß and BMP pathways is an early event in atherosclerotic lesion formation. No significant relationships were found between Smad phosphorylation and vessel wall inflammation or plaque vulnerability. |
Autor/es principal/es: | van Dijk, R.A. Engels, C.C Schaapherder, A.F Mulder-Stapel, A. ten Dijke, P. Hamming, J.F Lindeman, J.H.N. |
URI: | http://hdl.handle.net/10201/52417 |
Tipo de documento: | info:eu-repo/semantics/article |
Número páginas / Extensión: | 10 |
Derechos: | info:eu-repo/semantics/openAccess |
Aparece en las colecciones: | Vol.27, nº 3 (2012) |
Ficheros en este ítem:
Fichero | Descripción | Tamaño | Formato | |
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van-Dijk-27-387-396-2012.pdf | 3,08 MB | Adobe PDF | Visualizar/Abrir |
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