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Título: | Negative/Low HER2 expression alone or combined with E-cadherin positivity is predictive of better prognosis in patients with breast carcinoma |
Fecha de publicación: | 2012 |
Editorial: | F. Hernandez y JuanF. Madrid. Universidad de Murcia. Departamento de Biología Celular e Histología. |
Cita bibliográfica: | Histology and Histopatholgy. Volume 27, number 3 (March), 2012 |
ISSN: | 1699-5848 0213-3911 |
Materias relacionadas: | CDU::5 - Ciencias puras y naturales::57 - Biología |
Palabras clave: | Breast cancer Biomarkers |
Resumen: | The loss of E-cadherin expression leads to absence of tissue integrity, an essential step in tumor progression. Methylation of CpG islands in the promoter region of the CDH1 gene coding E-cadherin might be an alternative for gene silencing. In the present study, we investigate the expression of E-cadherin and hormone receptors in invasive ductal breast carcinoma (IDCs). Protein expression was analysed immunohistochemically in 87 cases, including 26 familial tumors. The most interesting results revealed a significantly reduced E-cadherin expression in cases with familial history compared to sporadic tumors (p=0.009), as well as with tumors ≤5cm (p=0.022). Moreover, HER2 over-expression was associated with distant metastasis (p=0.011) and overall survival (p log rank=0.028). Tumors displaying negative/low HER2 expression combined with E-cadherin positivity confer better patient survival (p=0.052). Triple Negative tumors (TN) were more frequently found in patients with advanced grade (GIII) (p=0.001) and TNM (III+IV) (p=0.018) which supports the aggressive behavior of TN tumors. On the other hand, hypermethylation of CDH1 gene promoter was observed in 46% of hereditary cases and strongly associated with loss of E-cadherin expression (p=0.002). Furthermore, patients with unmethylated CDH1 pattern have a better 5-year disease free survival (p=0.021). In conclusion, in patients with hereditary breast cancer, the CpG methylation event contributes to the loss of E-cadherin expression. On the other hand, HER2 over-expression is predictive of worse prognosis, either alone or combined with loss of E-cadherin expression in Tunisian patients with breast cancer. |
Autor/es principal/es: | Karray-Chouayekh, Sondes Trifa, Fatma Khabir, Abdelmajid Sellami-Boudawara, Tahia Frikha, Mounir Gargouri, Ali Mokdad-Gargouri, Raja |
URI: | http://hdl.handle.net/10201/52416 |
Tipo de documento: | info:eu-repo/semantics/article |
Número páginas / Extensión: | 9 |
Derechos: | info:eu-repo/semantics/openAccess |
Aparece en las colecciones: | Vol.27, nº 3 (2012) |
Ficheros en este ítem:
Fichero | Descripción | Tamaño | Formato | |
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Karray-Chouayekh-27-377-385-2012.pdf | 3,16 MB | Adobe PDF | Visualizar/Abrir |
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