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Title: Tumor-associated fibroblasts (Part I): active stromal participants in tumor development and progression?
Issue Date: 2002
Publisher: Murcia: F. Hernández
Citation: Histology and histopathology, Vol. 17, nº 2 (2002)
ISSN: 1699-5848
Related subjects: CDU::6 - Ciencias aplicadas::61 - Medicina::616 - Patología. Medicina clínica. Oncología
Keywords: Desmoplasia
Abstract: Phenotypic and functional characteristics of tumor associated fibroblasts (TAF) in contrast to normal fibroblasts are re v i e wed in this first synopsis (part I). Terms as tumor stroma, desmo-plasia, T A F , myofibroblast, and fetal-type fibroblast are defined, and experimental systems to study heterologous cell interactions are presented. While we only start to gather information on the genotype of T A F , a broad range of data deals with the e xpression profile of these cells, co v ering e.g. ECM and ECM-modulating molecules, growth factors and cytokines. Summarizing the recent state of kno w l e d g e indicates that TAF provide sources for tumor diagnosis and therap y , that ha v e to be further defined in an or g an- s p e c i f ic approach in terms of the functional impact on the tumor cell and its environment (see part II).
Primary author: Kunz-Schughart, L.A.
Knuechel, R.
Document type: info:eu-repo/semantics/article
Number of pages / Extensions: 23
Rights: info:eu-repo/semantics/openAccess
Appears in Collections:Vol.17, nº 2 (2002)

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