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Campo DC | Valor | Lengua/Idioma |
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dc.contributor.author | Orlova, Valeria V. | - |
dc.contributor.author | Liu, Zhen | - |
dc.contributor.author | Goumans, Marie-José | - |
dc.contributor.author | ten Dijke, Peter | - |
dc.date.accessioned | 2016-04-28T16:43:01Z | - |
dc.date.available | 2016-04-28T16:43:01Z | - |
dc.date.issued | 2011 | - |
dc.identifier.issn | 1699-5848 | - |
dc.identifier.issn | 0213-3911 | - |
dc.identifier.uri | http://hdl.handle.net/10201/49414 | - |
dc.description.abstract | Genetic studies in mice and humans have revealed a pivotal function for transforming growth factor-beta (TGF-β) in vascular development and maintenance of vascular homeostasis. Mice deficient for various TGF-β signaling components develop an embryonic lethality due to vascular defects. In patients, mutations in TGF-β receptors have been linked to vascular dysplasia like Hereditary Hemorrhagic Telangiectasia (HHT) and pulmonary arterial hypertension (PAH). Besides indirect effects by regulating the expression of angiogenic regulators, TGF-β also has potent direct effects on endothelial cell growth and migration, and we have proposed that TGF-β regulates the activation state of the endothelium via two opposing type I receptor/Smad pathways, activin receptor-like kinase (ALK)1 and ALK5. TGF-β is also critical for the differentiation of mural precursors into pericytes and smooth muscle cells. Furthermore, defective paracrine TGF-β signaling between endothelial and neighboring mural cells may be responsible for a leaky vessel phenotype that is characteristic of HHT. In this review, we discuss our current understanding of the TGF-β signaling pathway and its regulation of endothelial and vascular smooth muscle cell function. | es |
dc.format | application/pdf | es |
dc.format.extent | 12 | es |
dc.language | eng | es |
dc.publisher | F. Hernández y J.F. Madrid. Murcia: Universidad de Murcia, Departamento de Biología Celular e Histología. | es |
dc.relation.ispartof | Histology and histopathology, Vol. 26, nº9 (2011) | es |
dc.rights | info:eu-repo/semantics/openAccess | es |
dc.subject | Angiogenesis | es |
dc.subject | Pulmonary arterial hypertension | es |
dc.subject.other | 61 - Medicina | es |
dc.title | Controlling angiogenesis by two unique TGF-β type I receptor signaling pathways | es |
dc.type | info:eu-repo/semantics/article | es |
Aparece en las colecciones: | Vol.26, nº9 (2011) |
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Fichero | Descripción | Tamaño | Formato | |
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Orlova-26-1219-1230-2011.pdf | 759,31 kB | Adobe PDF | Visualizar/Abrir |
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