Please use this identifier to cite or link to this item: http://hdl.handle.net/10201/49413

Title: Review of acquired cystic disease-associated renal cell carcinoma with focus on pathobiological aspects
Issue Date: 2011
Publisher: F. Hernández y J.F. Madrid. Murcia: Universidad de Murcia, Departamento de Biología Celular e Histología.
ISSN: 1699-5848
0213-3911
Related subjects: 616 - Patología. Medicina clínica. Oncología
Keywords: Acquired cystic disease
Oxalate crystals
Abstract: Acquired cystic disease (ACD)-associated renal cell carcinoma (RCC) is a recently established entity. In this article, we introduce the general view of this new entity. Macroscopically, the disease exclusively occurs in ACD and may arise as a dominant mass or non-dominant masses. Histologically, the tumor is characterized by a microcystic pattern, neoplastic cells with an eosinophilic or oncocytic cytoplasm and frequent intratumoral oxalate crystal deposition. Prominent nucleoli of tumor cells are often observed. Immunohistochemically, neoplastic cells are generally positive for AMACR but negative for cytokeratin 7. Ultrastructurally, neoplastic cells contain abundant mitochondria in the cytoplasm. Genetically, the gain of chromosomes 3, 7, 17 and abnormality of the sex chromosome were frequently observed in several studies. In conclusion, ACD-associated RCC may be widely recognized as a distinct entity in the near future because this tumor is morphologically and genetically different from other renal tumor entities that have been previously established.
Primary author: Kuroda, Naoto
Ohe, Chisato
Mikami, Shuji
Hes, Ondrej
Michal, Michal
Brunelli, Matteo
Martignoni, Guido
Sato, Yasuharu
Yoshino, Tadashi
Kakehi, Yoshiyuki
Shuin, Taro
Lee, Gang-Hong
Published in: Histology and histopathology, Vol. 26, nº9 (2011)
URI: http://hdl.handle.net/10201/49413
Document type: info:eu-repo/semantics/article
Number of pages / Extensions: 4
Rights: info:eu-repo/semantics/openAccess
Appears in Collections:Vol.26, nº9 (2011)

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