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Campo DC | Valor | Lengua/Idioma |
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dc.contributor.author | Shakibaei, Mehdi | - |
dc.contributor.author | Buhrmann, C. | - |
dc.contributor.author | Mobasheri, A. | - |
dc.date.accessioned | 2016-04-27T18:41:04Z | - |
dc.date.available | 2016-04-27T18:41:04Z | - |
dc.date.issued | 2011 | - |
dc.identifier.issn | 1699-5848 | - |
dc.identifier.issn | 0213-3911 | - |
dc.identifier.uri | http://hdl.handle.net/10201/49388 | - |
dc.description.abstract | Tendons have a limited capacity for self-repair due to the low density and mitotic activity of tenocytes. Pro-inflammatory cytokines such as interleukin-1ß (IL-1ß) have been identified as the main initiators of tendinopathies, stimulating inflammation, apoptosis and extracellular matrix (ECM) degradation. The aim of this study was to evaluate the potential of Tendoactive®, a newly developed proprietary nutraceutical formulation that includes mucopolysaccharides, collagen and vitamin C, in an in vitro model of tendon inflammation. The effects of Tendoactive® were studied in primary cultures of human tenocytes treated with IL-1ß for up to 72 h. Expression of collagen type I, integrin ß1, cyclo-oxygenase-2 (COX-2), caspase-3 and matrix metalloproteinase-1 (MMP-1) was monitored by western blotting. The effects of Tendoactive® on the expression, phosphorylation and nuclear translocation of protein components of the NF-κB system were studied by western blotting and immunofluorescence respectively. Treatment of tenocytes with Tendoactive® suppressed IL-1ß-induced NF-κB activation and p65 nuclear translocation. These events correlated with down-regulation of NF-κB targets including COX-2, MMP-1 and activated caspase-3. Tendoactive® also reversed the IL-1ß-induced down-regulation of collagen type I and ß1-integrin receptor expression. These results indicate that Tendoactive® has nutraceutical potential as an anti-inflammatory agent for treating tendinopathy through suppression of NF-κB mediated IL-1ß catabolic signalling pathways in tenocytes. | es |
dc.format | application/pdf | es |
dc.format.extent | 13 | es |
dc.language | eng | es |
dc.publisher | F. Hernández y J.F. Madrid. Murcia: Universidad de Murcia, Departamento de Biología Celular e Histología. | es |
dc.relation.ispartof | Histology and histopathology, Vol.26, nº9 (2011) | es |
dc.rights | info:eu-repo/semantics/openAccess | es |
dc.subject | Tendinopathy | es |
dc.subject | Tendoactive® | es |
dc.subject.other | 61 - Medicina | es |
dc.title | Anti-inflammatory and anti-catabolic effects of TENDOACTIVE® on human tenocytes in vitro | es |
dc.type | info:eu-repo/semantics/article | es |
Aparece en las colecciones: | Vol.26, nº9 (2011) |
Ficheros en este ítem:
Fichero | Descripción | Tamaño | Formato | |
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Shakibaei-26-1173-1185-2011.pdf | 3,03 MB | Adobe PDF | Visualizar/Abrir |
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