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Campo DC | Valor | Lengua/Idioma |
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dc.contributor.author | Lu, Xiaoye | - |
dc.contributor.author | Lin, Fangfang | - |
dc.contributor.author | Fang, Huijuan | - |
dc.contributor.author | Yang, Xuesong | - |
dc.contributor.author | Qin, Li | - |
dc.date.accessioned | 2016-04-27T16:28:35Z | - |
dc.date.available | 2016-04-27T16:28:35Z | - |
dc.date.issued | 2011 | - |
dc.identifier.issn | 1699-5848 | - |
dc.identifier.issn | 0213-3911 | - |
dc.identifier.uri | http://hdl.handle.net/10201/49383 | - |
dc.description.abstract | Aim: Firstly to examine the expression characteristics of Musashi (Msi)-1 in fetal endometrium, reproductive normal endometrium, endometrial hyperplasia and endometrioid adenocarcinoma, next, to focus on exploring the possibility that Msi-1 serves as a marker of the endometrial stem cells in-situ. Methods: Immunohistochemical staining was performed to detect the expression of Msi-1 in 20 cases of fetal endometrium, 20 cases of normal endometrium, 20 cases of endometrial hyperplasia and 50 cases of endometrioid adenocarcinoma respectively. Results: In fetal endometrium, Msi-1 positive cells were observed from the 12th week in epithelium, but the number of Msi-1 positive cells decreased with an increase in gestational age. In reproductive normal endometrium, Msi-1 expression presented as dispersed single cell and cell groups in the stroma adjacent to the myometrium. In endometrial hyperplasia and endometrioid adenocarcinoma, Msi-1 expression significantly increased and was more widely distributed. Conclusions: Msi-1 positive cells mainly lie in the stroma of normal endometrium, and the distribution pattern is consistent with that of the speculated endometrial stem cells. The high expression of Msi-1 in fetal endometrium and endometrioid adenocarcinoma suggests that Msi-1 positive cells have several characteristics of stem cells, such as high proliferative potentiality and multipotency. Considering these factors, this makes Msi-1 potentially a promising stem cell marker. | es |
dc.format | application/pdf | es |
dc.format.extent | 7 | es |
dc.language | eng | es |
dc.publisher | F. Hernández y J.F. Madrid. Murcia: Universidad de Murcia, Departamento de Biología Celular e Histología. | es |
dc.relation.ispartof | Histology and histopathology, vol. 26, nº9 (2011) | es |
dc.rights | info:eu-repo/semantics/openAccess | es |
dc.subject | Endometrium | es |
dc.subject | Endometrial hyperplasia | es |
dc.subject.other | 61 - Medicina | es |
dc.title | Expression of a putative stem cell marker Musashi-1 in endometrium | es |
dc.type | info:eu-repo/semantics/article | es |
Aparece en las colecciones: | Vol.26, nº9 (2011) |
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Fichero | Descripción | Tamaño | Formato | |
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Lu-26-1127-1133-2011.pdf | 4,63 MB | Adobe PDF | Visualizar/Abrir |
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