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Título: | Low expression of Progesterone Receptor A in intermediate trophoblast of miscarriages |
Fecha de publicación: | 2011 |
Editorial: | Murcia: F. Hernández |
ISSN: | 1699-5848 0213-3911 |
Materias relacionadas: | 61 - Medicina |
Palabras clave: | Progesterone receptor A Estrogen receptor A Intermediate trophoblast |
Resumen: | Summary. Objective: To examine the potential differences in the expression of Progesterone Receptor A and Estrogen Receptor A in intermediate trophoblastic cells at the implantation site in elective abortions and miscarriages by immunohistochemistry. Study Design: Twenty two (22) samples of miscarriages and eighteen (18) samples of elective abortions were obtained during gestational weeks 6 to 12. Monoclonal antibodies against Cytokeratin 7 and prolactin were used to help discriminate between trophoblastic and decidual cells at the feto-maternal interface on formalin-fixed paraffin-embedded sections. Samples were then stained with ERA and PRA antibodies. Nuclear expression was considered positive. Staining intensity was measured according to a 4 grade scale. Statistical analysis of the results was performed using the Mann-Whitney test and the Wilcoxon signed rank test. Results: PRA expression in intermediate trophoblastic cells was significantly higher in elective abortions (control group) compared to miscarriages. ERA expression was uniformly negative in both groups. Conclusion: PRA expression is significantly lower in intermediate trophoblastic cells of miscarriages compared to elective abortion pregnancies. Although this could be solely a result of a secondary event, it is still an important finding in the effort to unravel the complex molecular pathobiology of spontaneous abortions. |
Autor/es principal/es: | Papamitsou, Theodora Chatzistamatiou, Maria Grammatikopoulou, Danai Papadopoulou, Kyriaki Lakis, Sotirios Economou, Zinon Papadopoulou, Chrisi Sioga, Antonia |
Forma parte de: | Histology and Histopathology,vol25, nº5, 2011 |
URI: | http://hdl.handle.net/10201/48633 |
Tipo de documento: | info:eu-repo/semantics/article |
Número páginas / Extensión: | 6 |
Derechos: | info:eu-repo/semantics/openAccess |
Aparece en las colecciones: | Vol.26, nº5 (2011) |
Ficheros en este ítem:
Fichero | Descripción | Tamaño | Formato | |
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Papamitsou-26-609-614-2011.pdf | 1,69 MB | Adobe PDF | Visualizar/Abrir |
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