Please use this identifier to cite or link to this item: http://hdl.handle.net/10201/48626

Title: Cytoplasmic expression of p33ING1b is correlated with tumorigenesis and progression of head and neck squamous cell carcinoma
Issue Date: 2011
Publisher: Murcia: F. Hernández
ISSN: 0213-3911
1699-5848
Related subjects: 61 - Medicina
Keywords: p33ING1b
14-3-3η
HNSCC
Abstract: Summary. To clarify the role of p33ING1b in tumorigenesis and progression of head and neck squamous cell carcinoma (HNSCC), we examined the expression and subcellular localization of p33ING1b in 214 HNSCC cases in parallel with 60 dysplasia samples and 48 normal epithelium samples by immunohistochemistry, and analyzed correlations of expression of p33ING1b in HNSCC cases with clinicopathological variables, apototic index and expression of 14-3-3η, p300, p21 and PCNA. Although 12% of HNSCC cases lost expression of p33ING1b, most cases of HNSCC retained expression of p33ING1b with levels similar to those in non-cancerous epithelia. Nuclear expression of p33ING1b was significantly decreased in HNSCC compared to normal epithelia. In contrast, cytoplasmic expression of p33ING1b was found to be significantly higher in HNSCC. An abundance of p33ING1b in cytoplasm positively correlated with poor differentiation and tumor progression. Corresponding to those clinicopathogical features, high expression of p33ING1b in the cytoplasm correlated with PCNA labelling index but in contrast, that in the nuclei correlated with apoptosis. In nuclei, p33ING1b is coexpressed with p300 and p21, implying its roles in tumor suppression. Elevated expression of 14-3-3η was associated with cytoplasmic expression of p33ING1b and immunofluorescence study suggested association of p33ING1b and 14-3-3η. Among three cell lines derived from oral SCC, poorly-differentiated SAS cells showed a relatively high expression of p33ING1b in cytoplasm with
Primary author: Li, Xiao-Han
Noguchi, Akira
Nishida, Takeshi
Takahashi, Hiroyuki
Zheng, Yang
Yang, Xiang-Hong
Masuda, Shinji
Kikuchi, Keiji
Takano, Yasuo
Published in: Histology and Histopathology,vol.26, nº5, 2011
URI: http://hdl.handle.net/10201/48626
Document type: info:eu-repo/semantics/article
Number of pages / Extensions: 11
Rights: info:eu-repo/semantics/openAccess
Temporary material: 1996-2006
Appears in Collections:Vol.26, nº5 (2011)

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