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Title: Different expression of the catalytic alpha subunits of the AMP activated protein kinase - an immunohistochemical study in human tissue
Issue Date: 2011
Publisher: Murcia: F. Hernández
ISSN: 1699-5848
Related subjects: 61 - Medicina
Keywords: AMPK
Abstract: Summary. AMPK is an ubiquitously distributed multienzyme complex. It is an important energy sensor and regulator of cellular metabolic activity. In this study we analyzed for the first time the cellular distribution of the catalytically active subunits AMPKα1 and α2 in different human tissues by immunohistochemistry. We found different expression patterns for both isoforms. AMPKα2 expression clearly dominates in skeletal myocytes and cardiomyocytes, whereas AMPKα1 dominates in a number of secreting cells, like mammary glands, islets of langerhans and cells of the colon crypts.
Primary author: Quentin, Thomas
Kitz, Julia
Steinmetz, Michael
Poppe, Andrea
Bär, Karin
Krätzner, Ralph
Published in: Histology and Histopathology, vol.26, 2011
Document type: info:eu-repo/semantics/article
Number of pages / Extensions: 8
Rights: info:eu-repo/semantics/openAccess
Temporary material: 2009
Geographic Materia: Alemania
Appears in Collections:Vol.26, nº5 (2011)

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