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Título: | Increased expression of annexin A7 in temporal lobe tissue of patients with refractory epilepsy |
Fecha de publicación: | 2011 |
Editorial: | Murcia: F. Hernández |
ISSN: | 1699-5848 0213-3911 |
Materias relacionadas: | 61 - Medicina |
Palabras clave: | Annexins A7 Refractory epilepsy Calcium homeostasis |
Resumen: | Annexin A7 is a member of the family of annexins, which are thought to function in the regulation of calcium homeostasis and the fusion of vesicles. Refractory epilepsy may be related to the imbalance of calcium homeostasis. Our aims are to investigate the expression of Annexin A7 in epileptic brains in comparison with human controls and to explore Annexin A7’s possible role in refractory epilepsy. We examined the expression of Annexin A7 via immunohistochemistry, double-label immuno-fluorescence and western blot. The expression of Annexin A7 was shown to be significantly increased in patients with refractory epilepsy. Double-label immunofluorescence and confocal microscopy disclosed Annexin A7 immunoreactivity in the neurons, which were recognized by the antibody of neuron specific enolase (NSE). The result showed that Annexin A7 may be involved in the pathophysiology of refractory epilepsy and may play a role in developing and maintaining the epilepsy. |
Autor/es principal/es: | Zhou, Sheng-nian Li, Cheng-shan Liu, L. Li, Y. Wang, X. Shen, Lan |
Forma parte de: | Histology and Histopathology, vol. 26, nº 5 (2011) |
URI: | http://hdl.handle.net/10201/48562 |
Tipo de documento: | info:eu-repo/semantics/article |
Número páginas / Extensión: | 9 |
Derechos: | info:eu-repo/semantics/openAccess |
Aparece en las colecciones: | Vol.26, nº5 (2011) |
Ficheros en este ítem:
Fichero | Descripción | Tamaño | Formato | |
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Zhou-26-571-579-2011.pdf | 1,81 MB | Adobe PDF | Visualizar/Abrir |
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