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Título: Role of Smad1 in diabetic nephropathy: Molecular mechanisms and implications as a diagnostic marker
Fecha de publicación: 2011
Editorial: Murcia: F. Hernández
ISSN: 1699-5848
Materias relacionadas: 61 - Medicina
Palabras clave: Diabetic nephropathy
Resumen: Diabetic nephropathy (DN) is the leading cause of chronic kidney failure. Moreover, DN is associated with elevated cardiovascular morbidity and mortality. DN is characterized by progressive expansion of the mesangial matrix and thickening of the glomerular basement membrane, resulting in the obliteration of glomerular capillaries. Advanced glycation endproducts (AGEs) produced as the result of hyperglycemia are known to stimulate the production of extracellular matrix (ECM) proteins, resulting in glomerulosclerosis. Exposure of cultured mesangial cells to AGEs results in a receptor-mediated upregulation of mRNA and protein secretion of type IV collagen (Col4), which is a major component of ECM. Here we review recent novel insights into the pathogenesis and diagnosis of DN, with a special emphasis on the emerging concept that diabetic glomerulosclerosis can result from activation of the signaling cascade leading to irreversible ECM overproduction. Finally, we describe signaling pathways involved in the initial change of DN and how these pathways can be manipulated for therapeutic benefit.
Autor/es principal/es: Abe, H.
Matsubara, Takeshi
Arai, Hidenori
Doi, Toshio
Forma parte de: Histology and histopathology, Vol. 26, nº 4 (2011)
URI: http://hdl.handle.net/10201/48470
Tipo de documento: info:eu-repo/semantics/article
Número páginas / Extensión: 11
Derechos: info:eu-repo/semantics/openAccess
Aparece en las colecciones:Vol.26, nº4 (2011)

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