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Título: | A morphometric study of the spatial patterns of TDP-43 immunoreactive neuronal inclusions in frontotemporal lobar degeneration (FTLD) with progranulin (GRN) mutation |
Fecha de publicación: | 2011 |
Editorial: | Murcia: F. Hernández |
ISSN: | 1699-5848 0213-3911 |
Materias relacionadas: | 616.8 - Neurología. Neuropatología. Sistema nervioso |
Palabras clave: | Frontotemporal lobar degeneration |
Resumen: | Mutations of the progranulin (GRN) gene are a major cause of familial frontotemporal lobar degeneration with transactive response (TAR) DNAbinding protein of 43kDa (TDP-43) proteinopathy (FTLD-TDP). We studied the spatial patterns of TDP-43 immunoreactive neuronal cytoplasmic inclusions (NCI) and neuronal intranuclear inclusions (NII) in histological sections of the frontal and temporal lobe in eight cases of FTLD-TDP with GRN mutation using morphometric methods and spatial pattern analysis. In neocortical regions, the NCI were clustered and the clusters were regularly distributed parallel to the pia mater; 58% of regions analysed exhibiting this pattern. The NII were present in regularly distributed clusters in 35% of regions but also randomly distributed in many areas. In neocortical regions, the sizes of the regular clusters of NCI and NII were 400-800 µm, approximating to the size of the modular columns of the cortico-cortical projections, in 31% and 36% of regions respectively. The NCI and NII also exhibited regularly spaced clustering in sectors CA1/2 of the hippocampus and in the dentate gyrus. The clusters of NCI and NII were not spatially correlated. The data suggest degeneration of the cortico-cortical and cortico-hippocampal pathways in FTLD-TDP with GRN mutation, the NCI and NII affecting different clusters of neurons. |
Autor/es principal/es: | Armstrong, Richard A. Cairns, Nigel J. |
Forma parte de: | Histology and histopathology, Vol. 26, nº 2 (2011) |
URI: | http://hdl.handle.net/10201/47801 |
Tipo de documento: | info:eu-repo/semantics/article |
Número páginas / Extensión: | 6 |
Derechos: | info:eu-repo/semantics/openAccess |
Aparece en las colecciones: | Vol.26, nº2 (2011) |
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Armstrong-26-185-190-2011.pdf | 472,2 kB | Adobe PDF | Visualizar/Abrir |
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