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Title: N-cadherin expression is involved in malignant behavior of head and neck cancer in relation to epithelial-mesenchymal transition
Issue Date: 2011
Publisher: Murcia: F. Hernández
ISSN: 1699-5848
Related subjects: 61 - Medicina
Keywords: Squamous cell carcinoma
Abstract: The loss of E-cadherin and the gain of Ncadherin expression are known as “cadherin switching”. Cadherin switching is a major hallmark of epithelialmesenchymal transition (EMT). EMT is a crucial process in cancer progression, providing cancer cells with the ability to escape from the primary focus, to invade stromal tissues and to migrate to distant regions. Although down-regulation of E-cadherin is well known in various cancers, there are a few studies on N-cadherin expression in cancer. Here, therefore, we investigated whether N-cadherin expression was associated with the progression of head and neck squamous cell carcinoma (HNSCC). First, we examined the expression of Ncadherin by immunohistochemistry and its correlation with clinico-pathological findings. High expression of N-cadherin was observed in 52 of 80 HNSCC cases and was significantly correlated with malignant behaviors. Next, we examined the correlation between N-cadherin and E-cadherin. Cadherin switching (high expression of N-cadherin and low expression of E-cadherin) was found in 30 of 80 HNSCC cases and was well correlated with histological differentiation, pattern of invasion and lymph node metastasis in HNSCC cases. Moreover, we examined the expression of N-cadherin and E-cadherin by RT-PCR in 16 HNSCC cell lines to confirm the immunohistochemical findings. N-cadherin expression was observed in 7 of 16 HNSCC cells, and cadherin switching was observed in 2 HNSCC cells. Interestingly, HNSCC cells with cadherin switching have EMT features. In conclusion, we suggest that i) N-cadherin may play an important role in malignant behaviors of HNSCC, and ii) cadherin switching might be considered as a discrete critical event in EMT and metastatic potential of HNSCC.
Primary author: Nguyen, Phuong Thao
Kudo, Yasusei
Yoshida, Maki
Kamata, Nobuyuki
Ogawa, Ikuko
Takata, Takashi
Published in: Histology and histopathology, Vol. 26, nº 2 (2011)
Document type: info:eu-repo/semantics/article
Number of pages / Extensions: 10
Rights: info:eu-repo/semantics/openAccess
Appears in Collections:Vol.26, nº2 (2011)

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