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Título: Role of neutrophil-derived matrix metalloproteinase-9 in tissue regeneration
Fecha de publicación: 2010
Editorial: Murcia: F. Hernández
ISSN: 1699-5848
Materias relacionadas: 576 - Biología celular y subcelular. Citología
Palabras clave: Angiogenesis
Resumen: Ischemic tissue regeneration depends on neovascularization, the growth of new blood vessels. Bone marrow (BM)-derived cells, including neutrophils, have been shown to contribute to neovascularization during hind limb ischemia and inflammation. Neutrophils produce a broad array of angiogenic growth factors and proteases, which promote remodeling of arterioles into arteries through proteolytic mechanisms. Matrix metalloproteinases (MMPs) have been shown to play a role in the recruitment of neutrophils to sites of inflammation, which requires the extravascular migration of neutrophils through the extracellular matrix. Neutrophils control critical steps during angiogenesis and neutrophil-derived MMPs can promote neoangiogenesis, and collateral growth and perfusion recovery, in part by liberating vital angiogenic growth factors, including vascular endothelial growth factor-A (VEGF-A). This review focuses on the role of neutrophils as key players in the control of the angiogenic process during ischemic tissue regeneration. Aspects of neutrophil regulation, in particular regulation by its major growth factor granulocyte colonystimulating factor (G-CSF), the role of the unique, readily available, neutrophil-derived MMP-9, and the functional consequences of this MMP-9 activation for angiogenesis, such as MMP-mediated release of biologically relevant cytokines from the matrix and cell surfaces, will be discussed.
Autor/es principal/es: Heissig, Beate
Nishida, Chiemi
Tashiro, Yoshihiko
Sato, Yayoi
Ishihara, Makoto
Ohki, Makiko
Gritli, Ismael
Rosenkvist, Jeanette
Hattori, Koichi
Forma parte de: Histology and histopathology, Vol. 25, nº 6 (2010)
URI: http://hdl.handle.net/10201/46511
Tipo de documento: info:eu-repo/semantics/article
Número páginas / Extensión: 6
Derechos: info:eu-repo/semantics/openAccess
Aparece en las colecciones:Vol.25, nº6 (2010)

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