Por favor, use este identificador para citar o enlazar este ítem:
http://hdl.handle.net/10201/46508
Twittear
Título: | Oxidized regenerated cellulose does not prevent the formation of experimental postoperative perineural fibrosis assessed by digital analysis |
Fecha de publicación: | 2010 |
Editorial: | Murcia: F. Hernández |
ISSN: | 1699-5848 0213-3911 |
Materias relacionadas: | 616.7 - Patología de los órganos de la locomoción. Sistema locomotor y esquelético |
Palabras clave: | Fibrosis Rats |
Resumen: | Introduction: It is difficult to prevent and treat intra- and peri-neural fibrosis after peripheral nerve surgery. Many authors have attempted to develop and verify the effectiveness of substances to decrease the formation of adherences in different tissues. Material and Methods: this study aimed to assess the effectiveness of a barrier of oxidized regenerated cellulose (ORC) to reduce adherence and perineural fibrosis in a model of surgical perineural induced fibrosis in rat sciatic nerve in 40 rats. After tissue aggression, the nerve of the right rear limb was wrapped in ORC and the left limb served as control. Animals were killed at 3 and 6 weeks, and nerves and muscle mass were extracted en bloc. Connective tissue was quantified by conventional histopathological techniques and Fibrosis HR® automatic image analysis. Results: No significant differences were found in intra- or peri-neural induced fibrosis between control nerves (6.88% and 8.90%, respectively) and treated nerves (6.57% and 9.90%) at 3 or 6 weeks (10.41% and 12.51% in controls; 11.85% and 15.72% in treated nerves). Inflammatory phenomena and granulomatous reactions were more frequent in treated animals. Conclusions: ORC conferred no advantage in prevention of nerve fibrosis and might have interfered with healing. |
Autor/es principal/es: | Hernández Cortés, Pedro Peregrina, Magdalena Aneiros Fernández, José Tassi, Mohamed Pajares López, Miguel Toledo, Miguel O’Valle, Francisco |
Forma parte de: | Histology and histopathology, Vol. 25, nº 6 (2010) |
URI: | http://hdl.handle.net/10201/46508 |
Tipo de documento: | info:eu-repo/semantics/article |
Número páginas / Extensión: | 7 |
Derechos: | info:eu-repo/semantics/openAccess |
Aparece en las colecciones: | Vol.25, nº6 (2010) |
Ficheros en este ítem:
Fichero | Descripción | Tamaño | Formato | |
---|---|---|---|---|
Oxidized regenerated cellulose.pdf | 1,76 MB | Adobe PDF | Visualizar/Abrir |
Los ítems de Digitum están protegidos por copyright, con todos los derechos reservados, a menos que se indique lo contrario.