Por favor, use este identificador para citar o enlazar este ítem: http://hdl.handle.net/10201/46321

Registro completo de metadatos
Campo DCValorLengua/Idioma
dc.contributor.authorCookson, Victoria J.es
dc.contributor.authorChapman, Robertes
dc.date.accessioned2015-09-29T07:17:47Z-
dc.date.available2015-09-29T07:17:47Z-
dc.date.issued2010-
dc.identifier.issn0213-3911es
dc.identifier.urihttp://hdl.handle.net/10201/46321-
dc.description.abstractInteractions between the nuclear factor kappaB (NF-κB) family of proteins (RelA, RelB, c-Rel, p50 and p52) and DNA are vital for cells to function normally; for example, in the human myometrium, NF- κB-regulated pro-inflammatory mediators, including TNFα, IL-1ß, IL-8 and COX-2 are associated with the onset of labour. NF-κB, however, regulates the expression of over 400 genes, although it is unlikely these would all be activated in concert by a single inducer. At present, defining the role of the NF-κB RelA:p50 dimer, which governs a number of inflammatory promoters, is at the forefront of the parturition research field. However, to over-look the function of other family members and how they may regulate alternative signalling networks within reproductive tissues, only serves to ensure we will never fully understand the molecular circuitry influenced by this family of transcription factors. Consequently this review highlights other mechanisms by which the NF- κB family of regulators have been shown to function in other systems and how they may readily translate to understanding the regulation underpinning human parturition.es
dc.formatapplication/pdfes
dc.format.extent12es
dc.languageenges
dc.publisherMurcia : F. Hernándezes
dc.relation.ispartofHistology and histopathologyes
dc.rightsinfo:eu-repo/semantics/openAccesses
dc.subjectInflammationes
dc.subjectGene regulationes
dc.subject.other618 - Ginecología. Obstetriciaes
dc.titleNF - KB function in the human myometrium during pregnancy and parturitiones
dc.typeinfo:eu-repo/semantics/articlees
Aparece en las colecciones:Vol.25, nº7 (2010)

Ficheros en este ítem:
Fichero Descripción TamañoFormato 
NF KB function in the human myometrium during pregnancy and parturition.pdf2,15 MBAdobe PDFVista previa
Visualizar/Abrir


Los ítems de Digitum están protegidos por copyright, con todos los derechos reservados, a menos que se indique lo contrario.