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Title: Treadmill training increases the size of A cells from the L5 dorsal root ganglia in diabetic rats
Issue Date: 2010
Publisher: Murcia : F. Hernández
ISSN: 0213-3911
Related subjects: 61 - Medicina
Keywords: Diabetic neuropathy
Abstract: The aim of this study was to evaluate the effects of physical training on the L5 dorsal root ganglion (DRG) cells in streptozotocin diabetic rats. Male adult rats were divided into 3 groups: (control, diabetic and trained diabetic). Treadmill training was performed for 10 weeks (5 days/week, twice a day). Blood glucose concentrations and body weight were evaluated 48h after diabetes induction and every 30 days thereafter. Then, animals were killed and the right L5 DRG removed. Histological and morphometric analysis consisted of evaluating nuclear and cellular volumes and areas in A and B cells at light and ultrastructural levels. Blood glucose concentrations were higher in both diabetic groups vs controls at all periods. Body weights were lower in all diabetics vs controls at all periods after diabetes induction, with a significant time vs group interaction. In A cells, the cellular and nuclear volumes were lower than control animals only in the diabetic group; control and trained diabetic animals did not differ; in B cells the cellular and nuclear volumes were lower in diabetic and trained diabetic rats. The cellular areas of A cells were smaller in diabetic rats than in control and trained diabetic rats, while the cellular areas of B cells were smaller in the diabetic and trained groups. In conclusion, treadmill training was able to increase the size of A cells from the DRG in diabetic rats and improved the morphological features of these cells
Primary author: do Nascimento, Patricia S.
Malysz, Tais
Ilha, Jocemar
Araujo, Rafaela T.
Hermel, Erica E.S.
Kalil-Gaspar, Pedro I.
Faccioni-Heuser, María C.
Schaan, Beatriz D.
Achaval, Matilde
Published in: Histology and histopathology
Document type: info:eu-repo/semantics/article
Number of pages / Extensions: 14
Rights: info:eu-repo/semantics/openAccess
Appears in Collections:Vol.25, nº6 (2010)

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