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Título: | Pericentriolar material analyses in normal esophageal mucosa, Barrett’s metaplasia and adenocarcinoma |
Fecha de publicación: | 2010 |
Editorial: | Murcia : F. Hernández |
ISSN: | 0213-3911 |
Materias relacionadas: | 577 - Bioquímica. Biología molecular. Biofísica |
Palabras clave: | Metaplasia Immunohistochemistry |
Resumen: | Barrett’s esophagus metaplasia is a pre-cancerous condition caused by chronic esophagitis. Chromosomal instability (CIN) is common in Barrett’s cells: therefore, we investigated the possible presence of centrosomal aberrations (a main cause of CIN) by centrosomal protein immunostaining in paraffined esophageal samples of patients who developed a Barrett’s adenocarcinoma. In most (55%) patients, alterations of the pericentriolar material (PCM) signals were evident and consistently marked the transition between normal epithelium to metaplasia. The alterations could even be found in adjacent native squamous epithelium, Barrett’s mucosa and submucosal gland cells, as well as in the basal/epibasal layers of the mucosa and submucosal gland duct, which are the regions hosting esophageal stem and progenitor cells. These findings strongly support the hypothesis that the three esophageal histotypes (one being pathological) can have a common progenitor. Surprisingly, PCM defective signal eventually decreased with neoplastic progression, possibly to enhance the genome stability of advanced cancer cells. Importantly, PCM altered signals in Barrett’s mucosa and their apparent evolution in successive histopathological steps were correlated to adenocarcinoma aggressiveness, suggesting PCM as a possible prognostic marker for tumor relapse. Extending our observations in a prospective study might help in the development of new prevention protocols for adenocarcinoma patients |
Autor/es principal/es: | Segat, Daniela Cassaro, Mauro Dazzo, Emanuela Cavallini, Lucía Romualdi, Chiara Salvador, Renato Vitale, María Pia Vitiello, Libero Fassan, Matteo Rugge, Massimo Zaninotto, Giovanni Ancona, Ermanno Baroni, Mauricio David |
Forma parte de: | Histology and histopathology |
URI: | http://hdl.handle.net/10201/46308 |
Tipo de documento: | info:eu-repo/semantics/article |
Número páginas / Extensión: | 10 |
Derechos: | info:eu-repo/semantics/openAccess |
Aparece en las colecciones: | Vol.25, nº5 (2010) |
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Fichero | Descripción | Tamaño | Formato | |
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Pericentriolar material analyses in normal esophageal.pdf | 2,47 MB | Adobe PDF | Visualizar/Abrir |
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