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Title: Pericentriolar material analyses in normal esophageal mucosa, Barrett’s metaplasia and adenocarcinoma
Issue Date: 2010
Publisher: Murcia : F. Hernández
ISSN: 0213-3911
Related subjects: 577 - Bioquímica. Biología molecular. Biofísica
Keywords: Metaplasia
Abstract: Barrett’s esophagus metaplasia is a pre-cancerous condition caused by chronic esophagitis. Chromosomal instability (CIN) is common in Barrett’s cells: therefore, we investigated the possible presence of centrosomal aberrations (a main cause of CIN) by centrosomal protein immunostaining in paraffined esophageal samples of patients who developed a Barrett’s adenocarcinoma. In most (55%) patients, alterations of the pericentriolar material (PCM) signals were evident and consistently marked the transition between normal epithelium to metaplasia. The alterations could even be found in adjacent native squamous epithelium, Barrett’s mucosa and submucosal gland cells, as well as in the basal/epibasal layers of the mucosa and submucosal gland duct, which are the regions hosting esophageal stem and progenitor cells. These findings strongly support the hypothesis that the three esophageal histotypes (one being pathological) can have a common progenitor. Surprisingly, PCM defective signal eventually decreased with neoplastic progression, possibly to enhance the genome stability of advanced cancer cells. Importantly, PCM altered signals in Barrett’s mucosa and their apparent evolution in successive histopathological steps were correlated to adenocarcinoma aggressiveness, suggesting PCM as a possible prognostic marker for tumor relapse. Extending our observations in a prospective study might help in the development of new prevention protocols for adenocarcinoma patients
Primary author: Segat, Daniela
Cassaro, Mauro
Dazzo, Emanuela
Cavallini, Lucía
Romualdi, Chiara
Salvador, Renato
Vitale, María Pia
Vitiello, Libero
Fassan, Matteo
Rugge, Massimo
Zaninotto, Giovanni
Ancona, Ermanno
Baroni, Mauricio David
Published in: Histology and histopathology
Document type: info:eu-repo/semantics/article
Number of pages / Extensions: 10
Rights: info:eu-repo/semantics/openAccess
Appears in Collections:Vol.25, nº5 (2010)

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