Please use this identifier to cite or link to this item: http://hdl.handle.net/10201/42610

Title: Intralesional administration of allogeneic bone marrow stromal cells reduces functional deficits after intracerebral hemorrhage
Issue Date: 2010
Publisher: Murcia : F. Hernández
ISSN: 0213-3911
Related subjects: 616.8 - Neurología. Neuropatología. Sistema nervioso
Keywords: Intracerebral hemorrhage
Cell therapy
Abstract: When a severe neurological lesion occurs as a consequence of intracerebral bleeding, no effective treatment for improving the outcome is currently available. In the present study, intracerebral hemorrhage (ICH) was induced by stereotactic injection of 0.5 U of collagenase type IV in the striatum of adult Wistar rats, and three days later, intralesional administration of 2x106 allogeneic bone marrow stromal cells (BMSC) in saline (n:10), or saline only (n:10), was performed. In the following 30 days, functional outcome was evaluated in each animal by rotarod and the modified neurological severity score (mNSS) test. Progressive and functional improvement was observed in BMSC-transplanted rats compared with controls, together with morphological images suggesting that intracerebral administration of BMSC increases endogenous neurogenesis at the level of subventricular zone (SVZ). These findings suggest that local administration of allogeneic BMSC could be useful to reduce the neurological deficits caused by intracerebral hemorrhage
Primary author: Otero, L.
Bonilla, C.
Aguayo, C.
Zurita, M.
Vaquero, J.
Published in: Histology and histopathology
URI: http://hdl.handle.net/10201/42610
Document type: info:eu-repo/semantics/article
Number of pages / Extensions: 9
Rights: info:eu-repo/semantics/openAccess
Appears in Collections:Vol.25, nº4 (2010)



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