Please use this identifier to cite or link to this item: http://hdl.handle.net/10201/42593

Title: MCM proteins as diagnostic and prognostic tumor markers in the clinical setting
Issue Date: 2010
Publisher: Murcia : F. Hernández
ISSN: 0213-3911
Related subjects: 616 - Patología. Medicina clínica. Oncología
Keywords: Cell proliferation
Cancer
Abstract: Minichromosome maintenance (MCM)proteins are essential for the process of DNA replication,functioning as license components for the S-phase ofcell-cycle initiation and further exerting weak helicaseactivity to unwind DNA from its supercoiled state atreplication forks. The requirement for MCM proteins incycling cells and their absence in quiescent onessupports evidence for their potential clinical applicationas cell proliferation markers. In the last few years, asidefrom their utility as cell proliferation markers, theassessment of MCM expression levels in diverse humanmalignancies has been the focus of extensive research inan aim to facilitate tumor diagnosis and prognosis inclinical settings. The present article aims to review theavailable data so far concerning the clinical significanceof MCM protein expression in human neoplasia incomparison to conventional proliferative markers. Areview of the literature revealed that MCM expression isassociated with important clinicopathological parametersfor patient management and also exhibits significantdiagnostic and prognostic value in several malignancies.MCMs are characterized by higher specificity andsensitivity than the conventional proliferative markers,such as Ki-67 and PCNA, and are thus considered asdiagnostic and prognostic tools of greater clinicalsignificance in several types of human malignancy.
Primary author: Giaginis, constantinos
Vgenopoulou, Stephanie
Vielh, Philippe
Theocharis, Stamatios
Published in: Histology and histopathology
URI: http://hdl.handle.net/10201/42593
Document type: info:eu-repo/semantics/article
Number of pages / Extensions: 20
Rights: info:eu-repo/semantics/openAccess
Appears in Collections:Vol.25, nº3 (2010)



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