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Título: Carbonic anhydrase II is secreted from bovine parotid glands
Fecha de publicación: 2010
Editorial: Murcia : F. Hernández
ISSN: 0213-3911
Materias relacionadas: 636 - Veterinaria. Explotación y cría de animales. Cría del ganado y de animales domésticos
Palabras clave: Parotid gland
Resumen: Besides carbonic anhydrase VI (CA-VI),CA-II is suggested to be a second secreted isoenzyme inruminant saliva. Therefore, the aim of the present studywas to investigate the expression of salivary CA-II inbovine parotid glands at the protein level. Moreover, weintended to identify the cells which secrete the enzymeinto the saliva. Two commercially available CA-IIspecific antibodies were tested for use inimmunohistochemistry on frozen sections of bovineparotid tissue. Intense positive staining for CA-II wasfound in luminal duct cells and for the first time alsoinside the duct lumen, clearly demonstrating theexpression and secretion of salivary CA-II in bovineparotid glands. The presence of CA-II protein wasverified for parotid tissue and whole saliva usingimmunoblot analysis. Both salivary CA-II and CA-VIare highly active in supplying the alimentary tract withbicarbonate. It is suggested that a decrease in theexpression of either one of these enzymes might severelydisturb digestion and/or increase susceptibility toacidosis in ruminants.
Autor/es principal/es: Mau, M.
Kaiser, T.M.
Südekum, K.-H.
Publicado en: Histology and histopathology
URI: http://hdl.handle.net/10201/42592
Tipo de documento: info:eu-repo/semantics/article
Número páginas / Extensión: 9
Derechos: info:eu-repo/semantics/openAccess
Aparece en las colecciones:Vol.25, nº3 (2010)

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