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Título: Transcriptional regulation of the Oct4 gene, a master gene for pluripotency
Fecha de publicación: 2010
Editorial: Murcia : F. Hernández
ISSN: 0213-3911
Materias relacionadas: 616 - Patología. Medicina clínica. Oncología
Palabras clave: Epigenetics
Resumen: Oct4 is one of the most importanttranscription factors required to maintain anundifferentiated state (self-renewal) and pluripotency ofhuman and mouse embryonic stem (ES) cells as well asearly embryonic cells. In addition, Oct4 is the onlyknown transcription factor that has to be exogenouslyintroduced into differentiated cells to make inducedpluripotent stem (iPS) cells. Therefore, it is of greatimportance to understand howOct4transcription isregulated in ES cells and embryos and how it becomesactivated during iPS cell formation. In this article, wewill review the regulation of the mouse Oct4gene fromthe viewpoint of DNA methylation, binding of orphannuclear receptors, histone modifications and synergisticeffects with other pluripotency factors. We will also raiseseveral key questions that need to be addressed in futurework to improve our understanding of Oct4generegulation and its essential role in self-renewal andpluripotency.
Autor/es principal/es: Kellner, Steven
Kikyo, Nobuaki
Publicado en: Histology and histopathology
URI: http://hdl.handle.net/10201/42588
Tipo de documento: info:eu-repo/semantics/article
Número páginas / Extensión: 8
Derechos: info:eu-repo/semantics/openAccess
Aparece en las colecciones:Vol.25, nº3 (2010)

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