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Campo DC | Valor | Lengua/Idioma |
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dc.contributor.author | Wu, Lin | es |
dc.contributor.author | Yang, Wei | es |
dc.contributor.author | Chen, Lin-Xin | - |
dc.contributor.author | Chen, Shen-Ren | - |
dc.contributor.author | Zhang, Jin-Kun | - |
dc.date.accessioned | 2015-01-20T12:06:08Z | - |
dc.date.available | 2015-01-20T12:06:08Z | - |
dc.date.issued | 2010 | - |
dc.identifier.issn | 0213-3911 | es |
dc.identifier.uri | http://hdl.handle.net/10201/42580 | - |
dc.description.abstract | Human Papillomavirus (HPV)-associatedesophageal carcinoma (EC) is a high incidence tumorworldwide. Dendritic cell (DC)-based tumor vaccine isconsidered an alternative therapy to treat EC. Here wedeveloped a DC-based vaccine by transfecting cordblood CD34+stem cell-derived DC with HPV18E7gene, observed its biological characteristics and theantigen-specific T-cell cytotoxicity on EC cells inducedby HPV18E7-DC in vitro. Our results showed that 1)HPV18E7 gene transfer did not change the typicalmorphology of mature DC, 2) the representativephenotypes of mature DC (CD80, CD86, and CD83)were highly expressed in HPV18E7- DC (81.6%, 80.5%,and 86.6%, respectively), 3) the expression level of18E7 protein in HPV18E7-DC was 47.5%, and 4) thespecific cytotoxicity against EC cells was significantlyhigher than that in controls (p<0.01). This studyindicates the possibility of a DC-based immunotherapyin HPV-associated EC. | en_EN |
dc.format | application/pdf | es |
dc.format.extent | 7 | es |
dc.language | eng | es |
dc.publisher | Murcia : F. Hernández | es |
dc.relation.ispartof | Histology and histopathology | es |
dc.rights | info:eu-repo/semantics/openAccess | es |
dc.subject | Dendritic cell | es |
dc.subject | Immunotherapy | es |
dc.subject.other | 616 - Patología. Medicina clínica. Oncología | es |
dc.title | In vitro antigen-specific cytotoxic T cell response against esophageal carcinoma cells induced by HPV18E7-transfected dendritic cells | es |
dc.type | info:eu-repo/semantics/article | es |
Aparece en las colecciones: | Vol.25, nº2 (2010) |
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Fichero | Descripción | Tamaño | Formato | |
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In vitro antigenspecific cytotoxic T cell response against esophageal carcinoma cells induced by HPV18E7transfected dendritic cells.pdf | 699,21 kB | Adobe PDF | Visualizar/Abrir |
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