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Campo DC | Valor | Lengua/Idioma |
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dc.contributor.author | Cayli, Sevil | es |
dc.contributor.author | Sati, Leyla | es |
dc.contributor.author | Seval-Celik, Yasemin | - |
dc.contributor.author | Altug Tuncer, M. | - |
dc.contributor.author | Yaymaci, Bengi | - |
dc.contributor.author | Berkman, Zafer | - |
dc.contributor.author | Altug, Tuncay | - |
dc.contributor.author | Demir, Ramazan | - |
dc.date.accessioned | 2015-01-20T12:06:08Z | - |
dc.date.available | 2015-01-20T12:06:08Z | - |
dc.date.issued | 2010 | - |
dc.identifier.issn | 0213-3911 | es |
dc.identifier.uri | http://hdl.handle.net/10201/42579 | - |
dc.description.abstract | The preventive and therapeutic effects ofEicosapentaenoic acid (EPA) on diet-inducedhyperlipidemia in rabbits have been investigated.Eighteen New Zealand rabbits were randomly dividedinto three groups of 6 subjects each; experimental group-I (EG-I) was administered a cholesterol rich diet,experimental group-II (EG-II) was treated with EPA(300 mg/kg/d) following a cholesterol-rich diet and thecontrol group (CG) had a standard diet. Blood sampleswere collected at day 0 and at the 4th and 12th weeks ofEG-II to obtain serum levels of total cholesterol (TC),high density lipid-cholesterol (HDL-C), low densitylipid-cholesterol (LDL-C) and triglyceride (TG). Fromeach group tissue samples were collected from thecarotid artery for immunohistochemistry and electronmicroscopy. Our results showed that EPA couldsignificantly lower (p<0.001) serum TC, LDL-C, HDL-C and TG levels with a reduction of 35%; 55%; 44% and51%, respectively. Scanning and transmission electronmicroscopy results revealed that endothelial damage wasmore prominent in EG-I when compared to EG-II. Theruptured endothelial lining and damaged cellular surfacewas increased in EG-I when compared to EG-II.Ultrastructural observations showed that after EPAtreatment, the degeneration and cellular surface damageon the endothelium were also decreased. These biochemical and ultrastructural results suggestthat EPA is a potential drug which significantly lowersthe serum lipid profile and partially repairs endothelialdysfunction due to hyperlipidemia | en_EN |
dc.format | application/pdf | es |
dc.format.extent | 11 | es |
dc.language | eng | es |
dc.publisher | Murcia : F. Hernández | es |
dc.relation.ispartof | Histology and histopathology | es |
dc.rights | info:eu-repo/semantics/openAccess | es |
dc.subject | Cholesterol | es |
dc.subject | Atherosclerosis | es |
dc.subject | Rabbit | - |
dc.subject.other | 61 - Medicina | es |
dc.title | The effects of Eicosapentaenoic acid on the endothelium of the carotid artery of rabbits on a high-cholesterol diet | es |
dc.type | info:eu-repo/semantics/article | es |
Aparece en las colecciones: | Vol.25, nº2 (2010) |
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The effects of Eicosapentaenoic acid on the endothelium of the carotid artery of rabbits on a highcholesterol diet.pdf | 5,55 MB | Adobe PDF | Visualizar/Abrir |
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