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Title: Angiogenesis and liver fibrogenesis
Issue Date: 2009
Publisher: Murcia : F. Hernández
ISSN: 0213-3911
Related subjects: 616 - Patología. Medicina clínica. Oncología
Keywords: Angiogenesis
Hepatic stellate cells
Abstract: Angiogenesis is a dynamic, hypoxiastimulated and growth factor-dependent process, eventually leading to the formation of new vessels from pre-existing blood vessels. In the last decade experimental and clinical studies have described the occurrence of hepatic angiogenesis in a number of different pathophysiological conditions, including those involving inflammatory, fibrotic and ischemic features. In particular, the literature evidence indicates that hepatic angiogenesis is strictly associated with, and may even favour fibrogenic progression of chronic inflammatory liver diseases of different aetiology. In this review, current “in vivo” and “in vitro” evidence supporting the potential pathogenetic role of angiogenesis in chronic liver diseases will be reviewed in an attempt to outline cellular and molecular mechanisms involved, with a specific emphasis on the crucial role of hypoxic conditions and hepatic stellate cells (HSCs), particularly when activated to the myofibroblast-like pro-fibrogenic phenotype.
Primary author: Valfrè di Bonzo, Lorenzo
Novo, Erica
Cannito, Stefania
Busletta, Chiara
Paternostro, Claudia
Povero, Davide
Parola, Maurizio
Published in: Histology and histopathology
Document type: info:eu-repo/semantics/article
Number of pages / Extensions: 19
Rights: info:eu-repo/semantics/openAccess
Appears in Collections:Vol.24,nº10 (2009)

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