Por favor, use este identificador para citar o enlazar este ítem: http://hdl.handle.net/10201/37533

Título: Angiogenesis and liver fibrogenesis
Fecha de publicación: 2009
Editorial: Murcia : F. Hernández
ISSN: 0213-3911
Materias relacionadas: 616 - Patología. Medicina clínica. Oncología
Palabras clave: Angiogenesis
Hepatic stellate cells
Resumen: Angiogenesis is a dynamic, hypoxiastimulated and growth factor-dependent process, eventually leading to the formation of new vessels from pre-existing blood vessels. In the last decade experimental and clinical studies have described the occurrence of hepatic angiogenesis in a number of different pathophysiological conditions, including those involving inflammatory, fibrotic and ischemic features. In particular, the literature evidence indicates that hepatic angiogenesis is strictly associated with, and may even favour fibrogenic progression of chronic inflammatory liver diseases of different aetiology. In this review, current “in vivo” and “in vitro” evidence supporting the potential pathogenetic role of angiogenesis in chronic liver diseases will be reviewed in an attempt to outline cellular and molecular mechanisms involved, with a specific emphasis on the crucial role of hypoxic conditions and hepatic stellate cells (HSCs), particularly when activated to the myofibroblast-like pro-fibrogenic phenotype.
Autor/es principal/es: Valfrè di Bonzo, Lorenzo
Novo, Erica
Cannito, Stefania
Busletta, Chiara
Paternostro, Claudia
Povero, Davide
Parola, Maurizio
Forma parte de: Histology and histopathology
URI: http://hdl.handle.net/10201/37533
Tipo de documento: info:eu-repo/semantics/article
Número páginas / Extensión: 19
Derechos: info:eu-repo/semantics/openAccess
Aparece en las colecciones:Vol.24,nº10 (2009)

Ficheros en este ítem:
Fichero Descripción TamañoFormato 
Angiogenesis and liver fibrogenesis.pdf6,92 MBAdobe PDFVista previa

Los ítems de Digitum están protegidos por copyright, con todos los derechos reservados, a menos que se indique lo contrario.