Por favor, use este identificador para citar o enlazar este ítem:
http://hdl.handle.net/10201/36078
Twittear
Registro completo de metadatos
Campo DC | Valor | Lengua/Idioma |
---|---|---|
dc.contributor.author | Pizzi, Sara | es |
dc.contributor.author | Porzionato, Andrea | es |
dc.contributor.author | Pasquali, Claudio | - |
dc.contributor.author | Guidolin, Diego | - |
dc.contributor.author | Sperti, Cosino | - |
dc.contributor.author | Fogar, Paola | - |
dc.contributor.author | Macchi, Verónica | - |
dc.contributor.author | De Caro, Raffaelle | - |
dc.contributor.author | Pedrazzoli, Sergio | - |
dc.contributor.author | Parenti, Anna | - |
dc.date.accessioned | 2013-09-25T08:06:40Z | - |
dc.date.available | 2013-09-25T08:06:40Z | - |
dc.date.issued | 2009 | - |
dc.identifier.issn | 0213-3911 | es |
dc.identifier.uri | http://hdl.handle.net/10201/36078 | - |
dc.description.abstract | The purposes of this study were to evaluate the prognostic significance of Glut-1 expression in patients with pancreatic ductal adenocarcinoma, and to analyse its expression in pancreatic intraepithelial neoplasias (PanIN) and non invasive intraductal papillary mucinous neoplasms (IPMN). Glut-1 expression was studied by immunohistochemistry in 60 pancreatic ductal adenocarcinomas and scored on a 4- point scale (1: <25%; 2: 25-50%; 3: 50-75%; 4: >75%). Relationships between Glut-1 score, histological grade and MIB-1 score were evaluated by the Spearman rank correlation test. Significant correlations were found between Glut-1 expression and histological grade (P<0.001) and MIB-1 score (P<0.01). Significant prognostic factors by univariate analysis were stage (P<0.0001), histological grade (P<0.001) and Glut-1 expression (P<0.005). Independent prognostic factors after multivariate analysis were stage (P<0.001) and Glut-1 expression (P<0.05), stratified as <50% and >50%. The correlation of Glut-1 score with histological grade and MIB-1 score indicated a higher glucose uptake in poorly differentiated and highly proliferative pancreatic cancer cells. Glut-1 immunohistochemical expression provides a useful prognostic factor in pancreatic ductal adenocarcinoma. Glut-1 expression was not found in PanINs 1 but in 27.8% and 43.8% of PanINs 2 and 3, and was not found in IPMNs with lowand moderate-grade dysplasia but in 60% of IPMNs with high-grade dysplasia, indicating Glut-1 involvement in a relatively early phase of pancreatic carcinogenesis. | es |
dc.format | application/pdf | es |
dc.format.extent | 11 | es |
dc.language | eng | es |
dc.publisher | Murcia : F. Hernández | es |
dc.relation.ispartof | Histology and histopathology | es |
dc.rights | info:eu-repo/semantics/openAccess | es |
dc.subject | Pancreatic adenocarcinoma | es |
dc.subject | Survival | es |
dc.subject.other | 616 - Patología. Medicina clínica. Oncología | es |
dc.title | Glucose transporter-1 expression and prognostic significance in pancreatic carcinogenesis | es |
dc.type | info:eu-repo/semantics/article | es |
Aparece en las colecciones: | Vol.24, nº2 (2009) |
Ficheros en este ítem:
Fichero | Descripción | Tamaño | Formato | |
---|---|---|---|---|
Glucose transporter1 expression and prognostic significance in pancreatic carcinogenesis.pdf | 18,9 MB | Adobe PDF | Visualizar/Abrir |
Los ítems de Digitum están protegidos por copyright, con todos los derechos reservados, a menos que se indique lo contrario.