Por favor, use este identificador para citar o enlazar este ítem: http://hdl.handle.net/10201/36027

Título: Emerging biological functions of the Vaccinia-Related Kinase (VRK) family
Fecha de publicación: 2009
Editorial: Murcia : F. Hernández
ISSN: 0213-3911
Materias relacionadas: 576 - Biología celular y subcelular. Citología
Palabras clave: Protein kinase
Cell signalin
Resumen: The Vaccinia-Related Kinases (VRKs) branched off early from the family of casein kinase (CK) I and compose a relatively uncharacterized family of the kinome. The VRKs were discovered due to their close sequence relation to the vaccinia virus B1R serine/threonine kinase. They were first described in phosphorylation of transcription factors that led to the discovery of an autoregulatory mechanism between VRK and the tumor suppressor transcription factor p53. The relevance of VRKs has broadened recently by introduction of its members as essential regulators in cell signaling, nuclear envelope dynamics, chromatin modifications, apoptosis and cellular stress response. Several phosphorylation substrates have been described, as well as the first positive and negative regulators of VRK. We provide an overview of the VRKs across species and discuss the wide diversity of cellular and organismal requirements for this kinase family.
Autor/es principal/es: Klerkx, Elke P.F.
Lazo, Pedro A.
Askjaer, Peter
Publicado en: Histology and histopathology
URI: http://hdl.handle.net/10201/36027
Tipo de documento: info:eu-repo/semantics/article
Número páginas / Extensión: 11
Derechos: info:eu-repo/semantics/openAccess
Aparece en las colecciones:Vol.24, nº6 (2009)

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